Show simple item record

dc.contributor.authorShrine, Nicken
dc.contributor.authorGuyatt, Anna Len
dc.contributor.authorErzurumluoglu, A Mesuten
dc.contributor.authorJackson, Victoria Een
dc.contributor.authorHobbs, Brian Den
dc.contributor.authorMelbourne, Carl Aen
dc.contributor.authorBatini, Chiaraen
dc.contributor.authorFawcett, Katherine Aen
dc.contributor.authorSong, Kijoungen
dc.contributor.authorSakornsakolpat, Phuwanaten
dc.contributor.authorLi, Xingnanen
dc.contributor.authorBoxall, Ruthen
dc.contributor.authorReeve, Nicola Fen
dc.contributor.authorObeidat, Ma'enen
dc.contributor.authorZhao, Jing Huaen
dc.contributor.authorWielscher, Matthiasen
dc.contributor.authorWeiss, Stefanen
dc.contributor.authorKentistou, Katherine Aen
dc.contributor.authorKentistou, Katherine Aen
dc.contributor.authorCook, James Pen
dc.contributor.authorSun, Benen
dc.contributor.authorZhou, Jianen
dc.contributor.authorHui, Jennieen
dc.contributor.authorKarrasch, Stefanen
dc.contributor.authorImboden, Medeaen
dc.contributor.authorHarris, Sarah Een
dc.contributor.authorMarten, Jonathanen
dc.contributor.authorEnroth, Stefanen
dc.contributor.authorKerr, Shona Men
dc.contributor.authorSurakka, Idaen
dc.contributor.authorVitart, Veroniqueen
dc.contributor.authorLehtimäki, Terhoen
dc.contributor.authorAllen, Richard Jen
dc.contributor.authorBakke, Per Sen
dc.contributor.authorBeaty, Terri Hen
dc.contributor.authorBleecker, Eugene Ren
dc.contributor.authorBossé, Yohanen
dc.contributor.authorBrandsma, Corry-Ankeen
dc.contributor.authorChen, Zhengmingen
dc.contributor.authorCrapo, James Den
dc.contributor.authorDanesh, Johnen
dc.contributor.authorDeMeo, Dawn Len
dc.contributor.authorDudbridge, Franken
dc.contributor.authorEwert, Ralfen
dc.contributor.authorGieger, Christianen
dc.contributor.authorGulsvik, Amunden
dc.contributor.authorHansell, Anna Len
dc.contributor.authorHao, Keen
dc.contributor.authorHoffman, Joshua Den
dc.contributor.authorHokanson, John Een
dc.contributor.authorHomuth, Georgen
dc.contributor.authorJoshi, Peter Ken
dc.contributor.authorJoubert, Philippeen
dc.contributor.authorLangenberg, Claudiaen
dc.contributor.authorLi, Xuanen
dc.contributor.authorLi, Limingen
dc.contributor.authorLin, Kuangen
dc.contributor.authorLind, Larsen
dc.contributor.authorLocantore, Nicholasen
dc.contributor.authorLuan, Jian'anen
dc.contributor.authorMahajan, Anubhaen
dc.contributor.authorMaranville, Joseph Cen
dc.contributor.authorMurray, Alisonen
dc.contributor.authorNickle, David Cen
dc.contributor.authorPacker, Richarden
dc.contributor.authorParker, Margaret Men
dc.contributor.authorPaynton, Megan Len
dc.contributor.authorPorteous, David Jen
dc.contributor.authorPorteous, David Jen
dc.contributor.authorProkopenko, Dmitryen
dc.contributor.authorQiao, Dandien
dc.contributor.authorRawal, Rajeshen
dc.contributor.authorRunz, Heikoen
dc.contributor.authorSayers, Ianen
dc.contributor.authorSin, Don Den
dc.contributor.authorSmith, Blair Hen
dc.contributor.authorSoler Artigas, Maríaen
dc.contributor.authorSparrow, Daviden
dc.contributor.authorTal-Singer, Ruthen
dc.contributor.authorTimmers, Paul RHJen
dc.contributor.authorVan den Berge, Maartenen
dc.contributor.authorWhittaker, John Cen
dc.contributor.authorWoodruff, Prescott Gen
dc.contributor.authorYerges-Armstrong, Laura Men
dc.contributor.authorTroyanskaya, Olga Gen
dc.contributor.authorRaitakari, Olli Ten
dc.contributor.authorKähönen, Mikaen
dc.contributor.authorPolašek, Ozrenen
dc.contributor.authorGyllensten, Ulfen
dc.contributor.authorRudan, Igoren
dc.contributor.authorDeary, Ian Jen
dc.contributor.authorProbst-Hensch, Nicole Men
dc.contributor.authorSchulz, Holgeren
dc.contributor.authorJames, Alan Len
dc.contributor.authorWilson, James Fen
dc.contributor.authorStubbe, Beateen
dc.contributor.authorZeggini, Eleftheriaen
dc.contributor.authorJarvelin, Marjo-Riittaen
dc.contributor.authorWareham, Nicholasen
dc.contributor.authorSilverman, Edwin Ken
dc.contributor.authorHayward, Carolineen
dc.contributor.authorMorris, Andrew Pen
dc.contributor.authorButterworth, Adamen
dc.contributor.authorScott, Robert Aen
dc.contributor.authorWalters, Robin Gen
dc.contributor.authorMeyers, Deborah Aen
dc.contributor.authorCho, Michael Hen
dc.contributor.authorStrachan, David Pen
dc.contributor.authorHall, Ian Pen
dc.contributor.authorTobin, Martin Den
dc.contributor.authorWain, Louise Ven
dc.contributor.authorUnderstanding Society Scientific Group,en
dc.date.accessioned2019-01-22T00:30:52Z
dc.date.available2019-01-22T00:30:52Z
dc.date.issued2019-03en
dc.identifier.issn1061-4036
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288299
dc.description.abstractAbstract Reduced lung function predicts mortality and is key to the diagnosis of COPD. In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, one-half of which are new. In combination these variants strongly predict COPD in deeply-phenotyped patient populations. Furthermore, the combined effect of these variants showed generalisability across smokers and never-smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherSpringer Nature
dc.subjectUnderstanding Society Scientific Groupen
dc.subjectLungen
dc.subjectHumansen
dc.subjectPulmonary Disease, Chronic Obstructiveen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectRisk Factorsen
dc.subjectCase-Control Studiesen
dc.subjectSmokingen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectGenome-Wide Association Studyen
dc.titleNew genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.en
dc.typeArticle
prism.endingPage493
prism.issueIdentifier3en
prism.publicationDate2019en
prism.publicationNameNature geneticsen
prism.startingPage481
prism.volume51en
dc.identifier.doi10.17863/CAM.35615
dcterms.dateAccepted2018-11-27en
rioxxterms.versionofrecord10.1038/s41588-018-0321-7en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-03en
dc.contributor.orcidShrine, Nick [0000-0003-3641-4371]
dc.contributor.orcidGuyatt, Anna L [0000-0003-1860-6337]
dc.contributor.orcidErzurumluoglu, A Mesut [0000-0003-1322-8138]
dc.contributor.orcidJackson, Victoria E [0000-0002-9758-9784]
dc.contributor.orcidHobbs, Brian D [0000-0001-9564-0745]
dc.contributor.orcidFawcett, Katherine A [0000-0002-6675-2112]
dc.contributor.orcidSakornsakolpat, Phuwanat [0000-0002-4308-0974]
dc.contributor.orcidObeidat, Ma'en [0000-0002-5443-2752]
dc.contributor.orcidZhao, Jing Hua [0000-0003-4930-3582]
dc.contributor.orcidKentistou, Katherine A [0000-0002-3553-4315]
dc.contributor.orcidKentistou, Katherine A [0000-0002-5816-664X]
dc.contributor.orcidSun, Benjamin [0000-0001-6347-2281]
dc.contributor.orcidHui, Jennie [0000-0002-1653-2496]
dc.contributor.orcidMarten, Jonathan [0000-0001-6916-2014]
dc.contributor.orcidEnroth, Stefan [0000-0002-5056-9137]
dc.contributor.orcidVitart, Veronique [0000-0002-4991-3797]
dc.contributor.orcidAllen, Richard J [0000-0002-8450-3056]
dc.contributor.orcidBeaty, Terri H [0000-0002-7644-1705]
dc.contributor.orcidBossé, Yohan [0000-0002-3067-3711]
dc.contributor.orcidDanesh, John [0000-0003-1158-6791]
dc.contributor.orcidJoshi, Peter K [0000-0002-6361-5059]
dc.contributor.orcidLangenberg, Claudia [0000-0002-5017-7344]
dc.contributor.orcidLuan, Jian'an [0000-0003-3137-6337]
dc.contributor.orcidMahajan, Anubha [0000-0001-5585-3420]
dc.contributor.orcidMurray, Alison [0000-0003-4915-4847]
dc.contributor.orcidPacker, Richard [0000-0003-2459-1020]
dc.contributor.orcidPorteous, David J [0000-0002-3657-8205]
dc.contributor.orcidPorteous, David J [0000-0003-1249-6106]
dc.contributor.orcidSayers, Ian [0000-0001-5601-5410]
dc.contributor.orcidSmith, Blair H [0000-0002-5362-9430]
dc.contributor.orcidSparrow, David [0000-0002-3213-1107]
dc.contributor.orcidTal-Singer, Ruth [0000-0002-5275-8062]
dc.contributor.orcidTimmers, Paul RHJ [0000-0002-5197-1267]
dc.contributor.orcidVan den Berge, Maarten [0000-0002-9336-7340]
dc.contributor.orcidWoodruff, Prescott G [0000-0002-3529-2379]
dc.contributor.orcidTroyanskaya, Olga G [0000-0002-5676-5737]
dc.contributor.orcidKähönen, Mika [0000-0002-4510-7341]
dc.contributor.orcidRudan, Igor [0000-0001-6993-6884]
dc.contributor.orcidWilson, James F [0000-0001-5751-9178]
dc.contributor.orcidZeggini, Eleftheria [0000-0003-4238-659X]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidHayward, Caroline [0000-0002-9405-9550]
dc.contributor.orcidMorris, Andrew P [0000-0002-6805-6014]
dc.contributor.orcidButterworth, Adam [0000-0002-6915-9015]
dc.contributor.orcidWalters, Robin G [0000-0002-9179-0321]
dc.contributor.orcidCho, Michael H [0000-0002-4907-1657]
dc.contributor.orcidStrachan, David P [0000-0001-7854-1366]
dc.contributor.orcidTobin, Martin D [0000-0002-3596-7874]
dc.contributor.orcidUnderstanding Society Scientific Group, [0000-0003-4951-1867]
dc.identifier.eissn1546-1718
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idMRC (1508647)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idMRC (MC_PC_13048)
pubs.funder-project-idBritish Heart Foundation (RG/13/13/30194)
pubs.funder-project-idBritish Heart Foundation (RG/18/13/33946)
cam.orpheus.successThu Jan 30 10:53:24 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2019-09-30


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record