Dynamical differential expression (DyDE) reveals the period control mechanisms of the Arabidopsis circadian oscillator.
dc.contributor.author | Mombaerts, Laurent | |
dc.contributor.author | Carignano, Alberto | |
dc.contributor.author | Robertson, Fiona C | |
dc.contributor.author | Hearn, Timothy | |
dc.contributor.author | Junyang, Jin | |
dc.contributor.author | Hayden, David | |
dc.contributor.author | Rutterford, Zoe | |
dc.contributor.author | Hotta, Carlos T | |
dc.contributor.author | Hubbard, Katherine E | |
dc.contributor.author | Maria, Marti Ruiz C | |
dc.contributor.author | Yuan, Ye | |
dc.contributor.author | Hannah, Matthew A | |
dc.contributor.author | Mendes Silva Goncalves, Jorge | |
dc.contributor.author | Webb, Alex | |
dc.date.accessioned | 2019-01-22T00:31:09Z | |
dc.date.available | 2019-01-22T00:31:09Z | |
dc.date.issued | 2019-01 | |
dc.identifier.issn | 1553-734X | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/288310 | |
dc.description.abstract | The circadian oscillator, an internal time-keeping device found in most organisms, enables timely regulation of daily biological activities by maintaining synchrony with the external environment. The mechanistic basis underlying the adjustment of circadian rhythms to changing external conditions, however, has yet to be clearly elucidated. We explored the mechanism of action of nicotinamide in Arabidopsis thaliana, a metabolite that lengthens the period of circadian rhythms, to understand the regulation of circadian period. To identify the key mechanisms involved in the circadian response to nicotinamide, we developed a systematic and practical modeling framework based on the identification and comparison of gene regulatory dynamics. Our mathematical predictions, confirmed by experimentation, identified key transcriptional regulatory mechanisms of circadian period and uncovered the role of blue light in the response of the circadian oscillator to nicotinamide. We suggest that our methodology could be adapted to predict mechanisms of drug action in complex biological systems. | |
dc.format.medium | Electronic-eCollection | |
dc.language | eng | |
dc.publisher | Public Library of Science (PLoS) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Arabidopsis | |
dc.subject | Niacinamide | |
dc.subject | Arabidopsis Proteins | |
dc.subject | Gene Expression Profiling | |
dc.subject | Systems Biology | |
dc.subject | Gene Expression Regulation, Plant | |
dc.subject | Circadian Rhythm | |
dc.subject | Models, Biological | |
dc.subject | Transcriptome | |
dc.title | Dynamical differential expression (DyDE) reveals the period control mechanisms of the Arabidopsis circadian oscillator. | |
dc.type | Article | |
prism.issueIdentifier | 1 | |
prism.publicationDate | 2019 | |
prism.publicationName | PLoS Comput Biol | |
prism.startingPage | e1006674 | |
prism.volume | 15 | |
dc.identifier.doi | 10.17863/CAM.35626 | |
dcterms.dateAccepted | 2018-11-26 | |
rioxxterms.versionofrecord | 10.1371/journal.pcbi.1006674 | |
rioxxterms.version | VoR | |
rioxxterms.licenseref.startdate | 2019-01-31 | |
dc.contributor.orcid | Mombaerts, Laurent [0000-0002-8653-7348] | |
dc.contributor.orcid | Hearn, Timothy [0000-0001-6827-4196] | |
dc.contributor.orcid | Hotta, Carlos T [0000-0003-3349-6121] | |
dc.contributor.orcid | Hannah, Matthew A [0000-0002-4889-490X] | |
dc.contributor.orcid | Mendes Silva Goncalves, Jorge [0000-0002-5228-6165] | |
dc.contributor.orcid | Webb, Alex [0000-0003-0261-4375] | |
dc.identifier.eissn | 1553-7358 | |
rioxxterms.type | Journal Article/Review | |
pubs.funder-project-id | Biotechnology and Biological Sciences Research Council (BB/I015558/1) | |
pubs.funder-project-id | Biotechnology and Biological Sciences Research Council (BB/D017904/1) | |
pubs.funder-project-id | Biotechnology and Biological Sciences Research Council (BB/L02182X/1) | |
pubs.funder-project-id | Biotechnology and Biological Sciences Research Council (BB/S002251/1) | |
pubs.funder-project-id | Engineering and Physical Sciences Research Council (EP/I03210X/1) | |
pubs.funder-project-id | Biotechnology and Biological Sciences Research Council (BB/M00113X/1) | |
pubs.funder-project-id | Biotechnology and Biological Sciences Research Council (BB/M006212/1) | |
pubs.funder-project-id | Engineering and Physical Sciences Research Council (EP/E02761X/1) | |
cam.issuedOnline | 2019-01-31 | |
datacite.issupplementedby.url | https://doi.org/10.17863/CAM.34506 | |
cam.orpheus.success | Mon Jun 08 08:23:34 BST 2020 - The item has an open VoR version. | |
rioxxterms.freetoread.startdate | 2022-01-21 |
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