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dc.contributor.authorMombaerts, Laurent
dc.contributor.authorCarignano, Alberto
dc.contributor.authorRobertson, Fiona C
dc.contributor.authorHearn, Timothy
dc.contributor.authorJunyang, Jin
dc.contributor.authorHayden, David
dc.contributor.authorRutterford, Zoe
dc.contributor.authorHotta, Carlos T
dc.contributor.authorHubbard, Katherine E
dc.contributor.authorMaria, Marti Ruiz C
dc.contributor.authorYuan, Ye
dc.contributor.authorHannah, Matthew A
dc.contributor.authorMendes Silva Goncalves, Jorge
dc.contributor.authorWebb, Alex
dc.date.accessioned2019-01-22T00:31:09Z
dc.date.available2019-01-22T00:31:09Z
dc.date.issued2019-01
dc.identifier.issn1553-734X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288310
dc.description.abstractThe circadian oscillator, an internal time-keeping device found in most organisms, enables timely regulation of daily biological activities by maintaining synchrony with the external environment. The mechanistic basis underlying the adjustment of circadian rhythms to changing external conditions, however, has yet to be clearly elucidated. We explored the mechanism of action of nicotinamide in Arabidopsis thaliana, a metabolite that lengthens the period of circadian rhythms, to understand the regulation of circadian period. To identify the key mechanisms involved in the circadian response to nicotinamide, we developed a systematic and practical modeling framework based on the identification and comparison of gene regulatory dynamics. Our mathematical predictions, confirmed by experimentation, identified key transcriptional regulatory mechanisms of circadian period and uncovered the role of blue light in the response of the circadian oscillator to nicotinamide. We suggest that our methodology could be adapted to predict mechanisms of drug action in complex biological systems.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectArabidopsis
dc.subjectNiacinamide
dc.subjectArabidopsis Proteins
dc.subjectGene Expression Profiling
dc.subjectSystems Biology
dc.subjectGene Expression Regulation, Plant
dc.subjectCircadian Rhythm
dc.subjectModels, Biological
dc.subjectTranscriptome
dc.titleDynamical differential expression (DyDE) reveals the period control mechanisms of the Arabidopsis circadian oscillator.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2019
prism.publicationNamePLoS Comput Biol
prism.startingPagee1006674
prism.volume15
dc.identifier.doi10.17863/CAM.35626
dcterms.dateAccepted2018-11-26
rioxxterms.versionofrecord10.1371/journal.pcbi.1006674
rioxxterms.versionVoR
rioxxterms.licenseref.startdate2019-01-31
dc.contributor.orcidMombaerts, Laurent [0000-0002-8653-7348]
dc.contributor.orcidHearn, Timothy [0000-0001-6827-4196]
dc.contributor.orcidHotta, Carlos T [0000-0003-3349-6121]
dc.contributor.orcidHannah, Matthew A [0000-0002-4889-490X]
dc.contributor.orcidMendes Silva Goncalves, Jorge [0000-0002-5228-6165]
dc.contributor.orcidWebb, Alex [0000-0003-0261-4375]
dc.identifier.eissn1553-7358
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/I015558/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/D017904/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/L02182X/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/S002251/1)
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/I03210X/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/M00113X/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/M006212/1)
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/E02761X/1)
cam.issuedOnline2019-01-31
datacite.issupplementedby.urlhttps://doi.org/10.17863/CAM.34506
cam.orpheus.successMon Jun 08 08:23:34 BST 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2022-01-21


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International