Establishing the plane of symmetry for lumen formation and bilateral brain formation in the zebrafish neural rod.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Buckley, Clare https://orcid.org/0000-0003-3329-3973
Clarke, Jon
Abstract
The lumen of the zebrafish neural tube develops precisely at the midline of the solid neural rod primordium. This process depends on cell polarisation and cell rearrangements, both of which are manifest at the midline of the neural rod. The result of this cell polarisation and cell rearrangement is an epithelial tube that has overt mirror-symmetry, such that cell morphology and apicobasal polarisation are mirrored across the midline of the neural tube. This article discusses how this mirror-symmetry is established and proposes the hypothesis that positioning the cells' centrosomes to the midline of the neural rod is a key event in organising this process.
Description
Keywords
Cell division, Centrosome, Neural tube, Zebrafish, Animals, Brain, Cell Polarity, Neural Tube, Zebrafish
Journal Title
Semin Cell Dev Biol
Conference Name
Journal ISSN
1084-9521
1096-3634
1096-3634
Volume Title
31
Publisher
Elsevier BV