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Establishing the plane of symmetry for lumen formation and bilateral brain formation in the zebrafish neural rod.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Clarke, Jon 

Abstract

The lumen of the zebrafish neural tube develops precisely at the midline of the solid neural rod primordium. This process depends on cell polarisation and cell rearrangements, both of which are manifest at the midline of the neural rod. The result of this cell polarisation and cell rearrangement is an epithelial tube that has overt mirror-symmetry, such that cell morphology and apicobasal polarisation are mirrored across the midline of the neural tube. This article discusses how this mirror-symmetry is established and proposes the hypothesis that positioning the cells' centrosomes to the midline of the neural rod is a key event in organising this process.

Description

Keywords

Cell division, Centrosome, Neural tube, Zebrafish, Animals, Brain, Cell Polarity, Neural Tube, Zebrafish

Journal Title

Semin Cell Dev Biol

Conference Name

Journal ISSN

1084-9521
1096-3634

Volume Title

31

Publisher

Elsevier BV