Genetically predicted DNA methylation biomarkers and epithelial ovarian cancer risk: data from nearly 63,000 women of European descent
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Abstract
Ovarian cancer is one of the most deadly cancers among women in the United States (1) and around the world (2). Approximately 90% of ovarian neoplasms are epithelial ovarian cancer (EOC) (1), a heterogeneous disease that can be categorized into five major histotypes (1). Genetic factors have an important impact on EOC etiology and large-scale genome-wide association studies (GWAS) have identified 34 common risk loci for EOC to date (3). Of these, 27 are specific to the most common histotype, serous EOC (3). Yet known loci are estimated to account for only a small proportion (~6.4%) of EOC risk (3). Further, causal genes at most loci and the underlying pathogenic mechanisms remain to be identified.
Description
Keywords
31 Biological Sciences, 32 Biomedical and Clinical Sciences, 3211 Oncology and Carcinogenesis, 3105 Genetics, Ovarian Cancer, Rare Diseases, Genetics, Clinical Research, Cancer, Human Genome, Prevention, 2 Aetiology, 2.1 Biological and endogenous factors, Cancer, Biomarkers, Tumor, Carcinoma, Ovarian Epithelial, Cohort Studies, DNA Methylation, Female, Genetic Predisposition to Disease, Humans, Models, Genetic, Ovarian Neoplasms, Predictive Value of Tests, Risk, White People, Women's Health
Journal Title
Cancer Research
Conference Name
Journal ISSN
1538-7445
1538-7445
1538-7445
Volume Title
Publisher
American Association for Cancer Research
Publisher DOI
Sponsorship
Cancer Research UK (CB4150)
Cancer Research UK (C14303/A17197)
Medical Research Council (G1000143)
Cancer Research Uk (None)
Medical Research Council (G0401527)
Medical Research Council (MR/N003284/1)
Medical Research Council (G0401527/1)
Cancer Research UK (C14303/A17197)
Medical Research Council (G1000143)
Cancer Research Uk (None)
Medical Research Council (G0401527)
Medical Research Council (MR/N003284/1)
Medical Research Council (G0401527/1)