Genetically predicted DNA methylation biomarkers and epithelial ovarian cancer risk: data from nearly 63,000 women of European descent
Authors
Yang, Yaohua
Wu, Lang
Shu, Xiang
Kar, Siddhartha
White, Emily
Willett, Walter
Wolk, Alicja
Woo, Yin-Ling
Wu, Anna H
Yan, Li
Yannoukakos, Drakoulis
Chenevix-Trench, Georgia
Sellers, Thomas A
Zheng, Wei
Long, Jirong
Publication Date
2019-02-01Journal Title
Cancer Research
ISSN
1538-7445
Publisher
American Association for Cancer Research
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Yang, Y., Wu, L., Shu, X., Brenton, J., Kar, S., Tyrer, J., White, E., et al. (2019). Genetically predicted DNA methylation biomarkers and epithelial ovarian cancer risk: data from nearly 63,000 women of European descent. Cancer Research https://doi.org/10.1158/0008-5472.CAN-18-2726
Abstract
Ovarian cancer is one of the most deadly cancers among women in the United States (1) and around the world (2). Approximately 90% of ovarian neoplasms are epithelial ovarian cancer (EOC) (1), a heterogeneous disease that can be categorized into five major histotypes (1). Genetic factors have an important impact on EOC etiology and large-scale genome-wide association studies (GWAS) have identified 34 common risk loci for EOC to date (3). Of these, 27 are specific to the most common histotype, serous EOC (3). Yet known loci are estimated to account for only a small proportion (~6.4%) of EOC risk (3). Further, causal genes at most loci and the underlying pathogenic mechanisms remain to be identified.
Sponsorship
Cancer Research UK (CB4150)
Cancer Research UK (C14303/A17197)
Medical Research Council (G1000143)
Cancer Research Uk (None)
Medical Research Council (G0401527)
Medical Research Council (MR/N003284/1)
Identifiers
External DOI: https://doi.org/10.1158/0008-5472.CAN-18-2726
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288417
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Licence:
http://www.rioxx.net/licenses/all-rights-reserved
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