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dc.contributor.authorAdams, Kristin Nen
dc.contributor.authorVerma, Amiten
dc.contributor.authorGopalaswamy, Radhaen
dc.contributor.authorAdikesavalu, Harreshen
dc.contributor.authorSinghal, Dinesh Kumaren
dc.contributor.authorTripathy, Srikanthen
dc.contributor.authorRanganathan, Uma Devien
dc.contributor.authorSherman, David Ren
dc.contributor.authorUrdahl, Kevin Ben
dc.contributor.authorRamakrishnan, Lalitaen
dc.contributor.authorHernandez, Rafael Een
dc.date.accessioned2019-01-29T00:30:17Z
dc.date.available2019-01-29T00:30:17Z
dc.date.issued2019-04en
dc.identifier.issn0022-1899
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288442
dc.description.abstractMycobacterium tuberculosis develops tolerance to multiple antibiotics when residing in host macrophages. We demonstrate that macrophage-induced tolerance to rifampin is common across major lineages of M. tuberculosis except for Beijing family lineage 2 strains.
dc.format.mediumPrinten
dc.languageengen
dc.publisherOxford University Press
dc.subjectMacrophagesen
dc.subjectHumansen
dc.subjectMycobacterium tuberculosisen
dc.subjectTuberculosis, Multidrug-Resistanten
dc.subjectIsoniaziden
dc.subjectRifampinen
dc.subjectBacterial Proteinsen
dc.subjectATP-Binding Cassette Transportersen
dc.subjectAntitubercular Agentsen
dc.subjectMicrobial Sensitivity Testsen
dc.subjectDrug Resistance, Multiple, Bacterialen
dc.subjectLoss of Function Mutationen
dc.subjectTHP-1 Cellsen
dc.titleDiverse Clinical Isolates of Mycobacterium tuberculosis Develop Macrophage-Induced Rifampin Tolerance.en
dc.typeArticle
prism.endingPage1558
prism.issueIdentifier10en
prism.publicationDate2019en
prism.publicationNameThe Journal of infectious diseasesen
prism.startingPage1554
prism.volume219en
dc.identifier.doi10.17863/CAM.35730
dcterms.dateAccepted2019-01-29en
rioxxterms.versionofrecord10.1093/infdis/jiy710en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-04en
dc.contributor.orcidTripathy, Srikanth [0000-0002-8363-2606]
dc.contributor.orcidRamakrishnan, Lalita [0000-0003-0692-5533]
dc.contributor.orcidHernandez, Rafael E [0000-0003-4408-7411]
dc.identifier.eissn1537-6613
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (103950/Z/14/Z)
pubs.funder-project-idMedical Research Council (MR/N501864/1)
pubs.funder-project-idNational Institutes of Health (NIH) (7R37A1054503-13)
cam.orpheus.successThu Jan 30 10:52:56 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-04-30


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