In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.
Annals of clinical and translational neurology
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Bevan-Jones, W., Cope, T., Jones, S., Passamonti, L., Hong, Y., Fryer, T., Arnold, R., et al. (2019). In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.. Annals of clinical and translational neurology, 6 (2), 373-378. https://doi.org/10.1002/acn3.683
Neuroinflammation occurs in frontotemporal dementia, however its timing relative to protein aggregation and neuronal loss is unknown. Using positron emission tomography and magnetic resonance imaging to quantify these processes in a pre-symptomatic carrier of the 10+16 MAPT mutation, we show microglial activation in frontotemporal regions, despite a lack of protein aggregation or atrophy in these areas. The distribution of microglial activation better discriminated the carrier from controls than did protein aggregation at this pre-symptomatic disease stage. Our findings suggest an early role for microglial activation in frontotemporal dementia. Longitudinal studies are needed to explore the causality of this pathophysiological association.
Brain, Humans, Atrophy, tau Proteins, Positron-Emission Tomography, Magnetic Resonance Imaging, Longitudinal Studies, Heterozygote, Mutation, Middle Aged, Female, Frontotemporal Dementia
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
WELLCOME TRUST (103838/Z/14/Z)
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
MEDICAL RESEARCH COUNCIL (MR/M009041/1)
MEDICAL RESEARCH COUNCIL (MR/M024873/1)
External DOI: https://doi.org/10.1002/acn3.683
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288443
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/