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Learning to optimize perceptual decisions through suppressive interactions in the human brain.

Published version
Peer-reviewed

Type

Article

Change log

Abstract

Translating noisy sensory signals to perceptual decisions is critical for successful interactions in complex environments. Learning is known to improve perceptual judgments by filtering external noise and task-irrelevant information. Yet, little is known about the brain mechanisms that mediate learning-dependent suppression. Here, we employ ultra-high field magnetic resonance spectroscopy of GABA to test whether suppressive processing in decision-related and visual areas facilitates perceptual judgments during training. We demonstrate that parietal GABA relates to suppression of task-irrelevant information, while learning-dependent changes in visual GABA relate to enhanced performance in target detection and feature discrimination tasks. Combining GABA measurements with functional brain connectivity demonstrates that training on a target detection task involves local connectivity and disinhibition of visual cortex, while training on a feature discrimination task involves inter-cortical interactions that relate to suppressive visual processing. Our findings provide evidence that learning optimizes perceptual decisions through suppressive interactions in decision-related networks.

Description

Keywords

Adult, Brain, Decision Making, Female, Humans, Judgment, Learning, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Photic Stimulation, Visual Cortex, Visual Perception, Young Adult, gamma-Aminobutyric Acid

Journal Title

Nat Commun

Conference Name

Journal ISSN

2041-1723
2041-1723

Volume Title

10

Publisher

Springer Science and Business Media LLC
Sponsorship
European Commission (290011)
Biotechnology and Biological Sciences Research Council (BB/P021255/1)
Wellcome Trust (205067/Z/16/Z)
This work was supported by 717 funding to ZK from the Alan Turing Institute, the Biotechnology and Biological Sciences 718 Research Council (Grants: H012508, P021255), the European Community’s Seventh 719 Framework Programme (Grant FP7/ 2007–2013 under agreement PITN-GA 2011-290011), 720 and the Wellcome Trust (Grant 205067). CJS holds a Sir Henry Dale Fellowship, funded by 721 the Wellcome Trust and the Royal Society (102584/Z/13/Z). ELH is supported by the NIHR 722 Oxford Health Biomedical Research Centre. The Wellcome Centre for Integrative 723 Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z).
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