Learning to optimize perceptual decisions through suppressive interactions in the human brain.
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Frangou, P., Emir, U. E., Karlaftis, V., Nettekoven, C., Hinson, E. L., Larcombe, S., Bridge, H., et al. (2019). Learning to optimize perceptual decisions through suppressive interactions in the human brain.. Nature communications, 10 (1), 474. https://doi.org/10.1038/s41467-019-08313-y
Translating noisy sensory signals to perceptual decisions is critical for successful interactions in complex environments. Learning is known to improve perceptual judgments by filtering external noise and task-irrelevant information. Yet, the inhibitory brain mechanisms that suppress irrelevant signals during training remain largely unknown. Here, we employ ultra high field magnetic resonance spectroscopy of GABA to test whether suppressive processing in decision-related and visual areas facilitates perceptual judgments during training. We demonstrate that parietal GABA relates to suppression of task-irrelevant information, while learning-dependent changes in visual GABA relate to enhanced performance in target detection and feature discrimination tasks. Combining GABA measurements with functional brain connectivity demonstrates that training on a target detection task involves local connectivity and disinhibition of visual cortex, while training on a feature discrimination task involves inter-cortical interactions that relate to suppressive visual processing. Our findings provide evidence that learning optimizes perceptual decisions through suppressive interactions in decision-related networks.
Brain, Visual Cortex, Humans, gamma-Aminobutyric Acid, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Photic Stimulation, Learning, Visual Perception, Decision Making, Judgment, Adult, Female, Male, Young Adult
This work was supported by 717 funding to ZK from the Alan Turing Institute, the Biotechnology and Biological Sciences 718 Research Council (Grants: H012508, P021255), the European Community’s Seventh 719 Framework Programme (Grant FP7/ 2007–2013 under agreement PITN-GA 2011-290011), 720 and the Wellcome Trust (Grant 205067). CJS holds a Sir Henry Dale Fellowship, funded by 721 the Wellcome Trust and the Royal Society (102584/Z/13/Z). ELH is supported by the NIHR 722 Oxford Health Biomedical Research Centre. The Wellcome Centre for Integrative 723 Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z).
Wellcome Trust (205067/Z/16/Z)
European Commission (290011)
External DOI: https://doi.org/10.1038/s41467-019-08313-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288508
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/