Learning to optimize perceptual decisions through suppressive interactions in the human brain.
Springer Science and Business Media LLC
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Frangou, P., Emir, U. E., Karlaftis, V., Nettekoven, C., Hinson, E. L., Larcombe, S., Bridge, H., et al. (2019). Learning to optimize perceptual decisions through suppressive interactions in the human brain.. Nat Commun, 10 (1), 474. https://doi.org/10.1038/s41467-019-08313-y
Translating noisy sensory signals to perceptual decisions is critical for successful interactions in complex environments. Learning is known to improve perceptual judgments by filtering external noise and task-irrelevant information. Yet, little is known about the brain mechanisms that mediate learning-dependent suppression. Here, we employ ultra-high field magnetic resonance spectroscopy of GABA to test whether suppressive processing in decision-related and visual areas facilitates perceptual judgments during training. We demonstrate that parietal GABA relates to suppression of task-irrelevant information, while learning-dependent changes in visual GABA relate to enhanced performance in target detection and feature discrimination tasks. Combining GABA measurements with functional brain connectivity demonstrates that training on a target detection task involves local connectivity and disinhibition of visual cortex, while training on a feature discrimination task involves inter-cortical interactions that relate to suppressive visual processing. Our findings provide evidence that learning optimizes perceptual decisions through suppressive interactions in decision-related networks.
Brain, Visual Cortex, Humans, gamma-Aminobutyric Acid, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Photic Stimulation, Learning, Visual Perception, Decision Making, Judgment, Adult, Female, Male, Young Adult
Related research output: https://doi.org/10.17863/CAM.33382
This work was supported by 717 funding to ZK from the Alan Turing Institute, the Biotechnology and Biological Sciences 718 Research Council (Grants: H012508, P021255), the European Community’s Seventh 719 Framework Programme (Grant FP7/ 2007–2013 under agreement PITN-GA 2011-290011), 720 and the Wellcome Trust (Grant 205067). CJS holds a Sir Henry Dale Fellowship, funded by 721 the Wellcome Trust and the Royal Society (102584/Z/13/Z). ELH is supported by the NIHR 722 Oxford Health Biomedical Research Centre. The Wellcome Centre for Integrative 723 Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z).
European Commission (290011)
Biotechnology and Biological Sciences Research Council (BB/P021255/1)
Wellcome Trust (205067/Z/16/Z)
External DOI: https://doi.org/10.1038/s41467-019-08313-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288508
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/