An alternative mode of epithelial polarity in the Drosophila midgut
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Journal Title
PLoS Biology
ISSN
1545-7885
Publisher
Public Library of Science (PLoS)
Volume
16
Issue
10
Number
e3000041
Type
Article
This Version
VoR
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Chen, J., Sayadian, A., Lowe, N., Lovegrove, H., & St Johnston, R. (2018). An alternative mode of epithelial polarity in the Drosophila midgut. PLoS Biology, 16 (10. e3000041) https://doi.org/10.1371/journal.pbio.3000041
Abstract
Apical-basal polarity is essential for the formation and function of epithelial tissues, whereas loss of polarity is a hallmark of tumours. Studies in Drosophila have identified conserved polarity factors that define the apical (Crumbs, Stardust, Par-6, aPKC), junctional (Baz/Par-3) and basolateral (Scribbled, Discs large, Lgl) domains of epithelial cells1. Because these conserved factors mark equivalent domains in diverse vertebrate and invertebrate epithelial types, it is generally assumed that this system organises polarity in all epithelia. Here we show that this is not the case, as none of these canonical factors are required for the polarisation of the endodermal epithelium of the Drosophila adult midgut. Furthermore, unlike other Drosophila epithelia, the midgut forms occluding junctions above adherens junctions, as in vertebrates, and requires the integrin adhesion complex for polarity. Thus, Drosophila contains two types of epithelia that polarise by different mechanisms. Since knock-outs of canonical polarity factors often have little effect on the polarity of vertebrate epithelia, this diversity of polarity mechanisms is likely to be conserved in other animals.
Sponsorship
Wellcome Trust (080007/B/06/Z)
Identifiers
External DOI: https://doi.org/10.1371/journal.pbio.3000041
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288609
Rights
Attribution 4.0 International, Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
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