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dc.contributor.authorChen, Jiaen
dc.contributor.authorSayadian, Aram-Christopheren
dc.contributor.authorLowe, Nicken
dc.contributor.authorLovegrove, Hollyen
dc.contributor.authorSt Johnston, Roberten
dc.date.accessioned2019-01-31T10:32:25Z
dc.date.available2019-01-31T10:32:25Z
dc.identifier.issn1545-7885
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288609
dc.description.abstractApical-basal polarity is essential for the formation and function of epithelial tissues, whereas loss of polarity is a hallmark of tumours. Studies in Drosophila have identified conserved polarity factors that define the apical (Crumbs, Stardust, Par-6, aPKC), junctional (Baz/Par-3) and basolateral (Scribbled, Discs large, Lgl) domains of epithelial cells1. Because these conserved factors mark equivalent domains in diverse vertebrate and invertebrate epithelial types, it is generally assumed that this system organises polarity in all epithelia. Here we show that this is not the case, as none of these canonical factors are required for the polarisation of the endodermal epithelium of the Drosophila adult midgut. Furthermore, unlike other Drosophila epithelia, the midgut forms occluding junctions above adherens junctions, as in vertebrates, and requires the integrin adhesion complex for polarity. Thus, Drosophila contains two types of epithelia that polarise by different mechanisms. Since knock-outs of canonical polarity factors often have little effect on the polarity of vertebrate epithelia, this diversity of polarity mechanisms is likely to be conserved in other animals.
dc.publisherPublic Library of Science (PLoS)
dc.relation.isreplacedby1810/288737
dc.relation.isreplacedbyhttps://www.repository.cam.ac.uk/handle/1810/288737
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleAn alternative mode of epithelial polarity in the Drosophila midguten
dc.typeArticle
prism.issueIdentifier10en
prism.numbere3000041en
prism.publicationNamePLoS Biologyen
prism.volume16en
dc.identifier.doi10.17863/CAM.35892
dcterms.dateAccepted2018-10-02en
rioxxterms.versionofrecord10.1371/journal.pbio.3000041en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2018-10-02en
dc.contributor.orcidChen, Jia [0000-0003-0080-0748]
dc.contributor.orcidSt Johnston, Robert [0000-0001-5582-3301]
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (080007/B/06/Z)
cam.issuedOnline2018-10-19en
dc.identifier.urlhttps://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000041en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International