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The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas

Published version
Peer-reviewed

Type

Article

Change log

Authors

Turner, SD 

Abstract

The Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of members including c-JUN, c-FOS and ATF, is involved in mediating many biological processes such as proliferation, differentiation and cell death. Since their discovery, the role of AP-1 TFs in cancer development has been extensively analyzed. Multiple in vitro and in vivo studies have highlighted the complexity of these TFs, mainly due to their cell-type specific homo- or hetero-dimerization resulting in diverse transcriptional response profiles. However, as a result of the increasing knowledge of the role of AP-1 TFs in disease, these TFs are being recognized as promising therapeutic targets for various malignancies. In this review, we focus on the impact of deregulated expression of AP-1 TFs in CD30-positive lymphomas including Classical Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma.

Description

Keywords

Activator Protein-1 (AP-1), Anaplastic Large Cell Lymphoma (ALCL), CD-30, Classical Hodgkin Lymphoma (CHL), Peripheral T-cell Lymphoma (PTCL), Transcription Factors (TFs)

Journal Title

Cancers

Conference Name

Journal ISSN

2072-6694
2072-6694

Volume Title

10

Publisher

MDPI AG
Sponsorship
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (675712)