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Genome organization at different scales: nature, formation and function.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Serizay, Jacques 

Abstract

Since the discovery of chromosome territories, it has been clear that DNA within the nucleus is spatially organized. During the last decade, a tremendous body of work has described architectural features of chromatin at different spatial scales, such as A/B compartments, topologically associating domains (TADs), and chromatin loops. These features correlate with domains of chromatin marking and gene expression, supporting their relevance for gene regulation. Recent work has highlighted the dynamic nature of spatial folding and investigated mechanisms of their formation. Here we discuss current understanding and highlight key open questions in chromosome organization in animals.

Description

Keywords

Animals, Gene Expression Regulation, Genome, Humans

Journal Title

Curr Opin Cell Biol

Conference Name

Journal ISSN

0955-0674
1879-0410

Volume Title

52

Publisher

Elsevier BV
Sponsorship
Medical Research Council (1826632)
Wellcome Trust (092096/Z/10/Z)
Wellcome Trust (101863/Z/13/Z)
Cancer Research Uk (None)