Genome organization at different scales: nature, formation and function.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Serizay, Jacques
Ahringer, Julie https://orcid.org/0000-0002-7074-4051
Abstract
Since the discovery of chromosome territories, it has been clear that DNA within the nucleus is spatially organized. During the last decade, a tremendous body of work has described architectural features of chromatin at different spatial scales, such as A/B compartments, topologically associating domains (TADs), and chromatin loops. These features correlate with domains of chromatin marking and gene expression, supporting their relevance for gene regulation. Recent work has highlighted the dynamic nature of spatial folding and investigated mechanisms of their formation. Here we discuss current understanding and highlight key open questions in chromosome organization in animals.
Description
Keywords
Animals, Gene Expression Regulation, Genome, Humans
Journal Title
Curr Opin Cell Biol
Conference Name
Journal ISSN
0955-0674
1879-0410
1879-0410
Volume Title
52
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Medical Research Council (1826632)
Wellcome Trust (092096/Z/10/Z)
Wellcome Trust (101863/Z/13/Z)
Cancer Research Uk (None)
Wellcome Trust (092096/Z/10/Z)
Wellcome Trust (101863/Z/13/Z)
Cancer Research Uk (None)