Caenorhabditis elegans and the network control framework-FAQs.
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Authors
Yan, Gang
Chew, Yee Lian
Walker, Denise S
Barabási, Albert-László
Publication Date
2018-09-10Journal Title
Philos Trans R Soc Lond B Biol Sci
ISSN
0962-8436
Publisher
The Royal Society
Volume
373
Issue
1758
Language
eng
Type
Article
This Version
AM
Physical Medium
Electronic
Metadata
Show full item recordCitation
Towlson, E. K., Vertes, P., Yan, G., Chew, Y. L., Walker, D. S., Schafer, W. R., & Barabási, A. (2018). Caenorhabditis elegans and the network control framework-FAQs.. Philos Trans R Soc Lond B Biol Sci, 373 (1758) https://doi.org/10.1098/rstb.2017.0372
Abstract
Control is essential to the functioning of any neural system. Indeed, under healthy conditions the brain must be able to continuously maintain a tight functional control between the system's inputs and outputs. One may therefore hypothesize that the brain's wiring is predetermined by the need to maintain control across multiple scales, maintaining the stability of key internal variables, and producing behaviour in response to environmental cues. Recent advances in network control have offered a powerful mathematical framework to explore the structure-function relationship in complex biological, social and technological networks, and are beginning to yield important and precise insights on neuronal systems. The network control paradigm promises a predictive, quantitative framework to unite the distinct datasets necessary to fully describe a nervous system, and provide mechanistic explanations for the observed structure and function relationships. Here, we provide a thorough review of the network control framework as applied to Caenorhabditis elegans (Yan et al. 2017 Nature550, 519-523. (doi:10.1038/nature24056)), in the style of Frequently Asked Questions. We present the theoretical, computational and experimental aspects of network control, and discuss its current capabilities and limitations, together with the next likely advances and improvements. We further present the Python code to enable exploration of control principles in a manner specific to this prototypical organism.This article is part of a discussion meeting issue 'Connectome to behaviour: modelling C. elegans at cellular resolution'.
Keywords
Nerve Net, Neurons, Motor Neurons, Animals, Caenorhabditis elegans, Locomotion, Connectome
Sponsorship
MQ: Transforming Mental Health (MQ17-24 Vertes)
Medical Research Council (MR/K020706/1)
Identifiers
External DOI: https://doi.org/10.1098/rstb.2017.0372
This record's URL: https://www.repository.cam.ac.uk/handle/1810/289012
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http://www.rioxx.net/licenses/all-rights-reserved
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