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Commentary on: Validation of a CD30 Enzyme-Linked Immunosorbant Assay for the Rapid Detection of Breast Implant-Associated Anaplastic Large Cell Lymphoma.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Turner, Suzanne D 
Wright, Penny 

Abstract

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon and emerging entity. It is a T-cell lymphoma that is usually localised within a late-onset peri-implant seroma that develops, on average, at 10 years after implant placement. In those cases limited to the seroma fluid, treatment in the form of complete capsulectomy by surgical excision may be curative1. However, for some patients, disease presents as a solid mass extending beyond the implant capsule and/or involving lymph nodes. These patients, in addition to surgery, require conventional chemotherapy and the antibody-drug conjugate brentuximab vedotin, which selectively targets tumor cells expressing the CD30 antigen has been shown to have superior activity in some cases2,3.

Description

Keywords

Breast Implantation, Breast Implants, Breast Neoplasms, Humans, Ki-1 Antigen, Lymphoma, Large-Cell, Anaplastic

Journal Title

Aesthet Surg J

Conference Name

Journal ISSN

1090-820X
1527-330X

Volume Title

40

Publisher

Oxford University Press (OUP)