Transcriptional regulation of the genes involved in protein metabolism and processing in Saccharomyces cerevisiae.
FEMS yeast research
Oxford University Press
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Dikicioglu, D., Nightingale, D., Wood, V., Lilley, K., & Oliver, S. (2019). Transcriptional regulation of the genes involved in protein metabolism and processing in Saccharomyces cerevisiae.. FEMS yeast research, 19 (2)https://doi.org/10.1093/femsyr/foz014
Topological analysis of large networks, which focus on a specific biological process or on related biological processes, where functional coherence exists among the interacting members, may provide a wealth of insight into cellular functionality. This work presents an unbiased systems approach to analyze genetic, transcriptional regulatory, and physical interaction networks of yeast genes possessing such functional coherence to gain novel biological insight. The present analysis identified only a few transcriptional regulators amongst a large gene cohort associated with the protein metabolism and processing in yeast. These transcription factors are not functionally required for the maintenance of these tasks in growing cells. Rather, they are involved in rewiring gene transcription in response to such major challenges as starvation, hypoxia, DNA damage, heat shock, or the accumulation of unfolded proteins. Indeed, only a subset of these proteins were captured empirically in the nuclear-enriched fraction of non-stressed yeast cells, suggesting that the transcriptional regulation of protein metabolism and processing in yeast is primarily concerned with maintaining cellular robustness in the face of threat by either internal or external stressors.
Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Transcription Factors, Transcription, Genetic, Gene Expression Regulation, Fungal, Protein Processing, Post-Translational, Gene Regulatory Networks
EC FP7 CP (289126)
Isaac Newton Trust (16.08(am))
Leverhulme Trust (ECF-2016-681)
External DOI: https://doi.org/10.1093/femsyr/foz014
This record's URL: https://www.repository.cam.ac.uk/handle/1810/289213