Masked priming tasks have been used widely to study early orthographic processes-the coding of letter position and letter identity. Recently, using masked priming in the same-different task Lupker, Nakayama, and Perea (2015a) reported finding a phonological priming effect with primes presented in Japanese Katakana, and English target words presented in the Roman alphabet, and based on this finding, suggested that previously reported effects in the same-different task in the literature could be based on phonology rather than orthography. In this article, the authors explain why the design of Lupker et al.'s experiment does not address this question; they then report 2 new experiments that do. The results indicate that the priming produced by orthographically similar primes in the same-different task for letter strings presented in the Roman alphabet is almost exclusively orthographic in origin, and phonology makes little contribution. The authors offer an explanation for why phonological priming was observed when the prime and target are presented in different scripts but not when they are presented in the same script. (PsycINFO Database Record (c) 2018 APA, all rights reserved).