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Non-aqueous formulations for ram and screen extrusion-spheronisation.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Zhang, M 
Rough, SL 
Ward, R 
Seiler, C 
Wilson, DI 

Abstract

The use of non-aqueous cellulose-based formulations for extrusion-spheronisation (E-S) is investigated. A 10 wt% hydroxypropyl cellulose/isopropyl alcohol solution (HPC/IPA) was identified as a suitable sticky liquid binder for preparing non-aqueous pastes. Preliminary tests were performed on a series of pastes using a ram as well as a laboratory roller screen extruder, since the former is commonly used in batch testing and the latter replicates the shear range in a manufacturing screen extruder. Pellets with acceptable size and shape distributions were obtained with Avicel® HFE-102 NF/HPC/IPA for ram E-S, and with Avicel® RC-591/HPC/IPA for screen E-S. Further investigation was performed with calcium carbonate added as a model active pharmaceutical ingredient. Both formulations were able to generate pellets with acceptable size and shape characteristics at up to 50 wt% carbonate loading: further work is required to optimise yields.

Description

Keywords

Extrusion, Non-aqueous formulations, Pellets, Spheronisation, 2-Propanol, Calcium Carbonate, Cellulose, Chemistry, Pharmaceutical, Drug Compounding, Excipients, Particle Size, Technology, Pharmaceutical

Journal Title

Int J Pharm

Conference Name

Journal ISSN

0378-5173
1873-3476

Volume Title

560

Publisher

Elsevier BV
Sponsorship
EPSRC Dorothy Hodgkin studentship for Min Zhang supported by MSD