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Testicular Cancer in 2017 – Large-scale sequencing studies improve understanding.

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Peer-reviewed

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Article

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Turnbull, Clare 

Abstract

Large-scale sequencing studies have improved our molecular understanding of testicular germ cell tumours (TGCTs), identifying molecular profiles associated with the genomic evolution and development of cisplatin resistance. Germline sequencing and large-scale genotyping are delineating the genomics of variants underpinning TGCT predisposition. Large studies of circulating microRNAs have demonstrated their potential for noninvasive diagnosis and disease monitoring.

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Nature Reviews Urology

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Nature Publishing Group

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Sponsorship
Isaac Newton Trust (1540 (f))
St Baldrick's Foundation (via Dana-Farber Cancer Institute) (2015-0743)