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dc.contributor.authorThomas, Luke Wen
dc.contributor.authorAshcroft, Margareten
dc.date.accessioned2019-02-16T00:30:30Z
dc.date.available2019-02-16T00:30:30Z
dc.date.issued2019-05en
dc.identifier.issn1420-682X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/289483
dc.description.abstractOxygen is required for the survival of the majority of eukaryotic organisms, as it is important for many cellular processes. Eukaryotic cells utilize oxygen for the production of biochemical energy in the form of adenosine triphosphate (ATP) generated from the catabolism of carbon rich fuels such as glucose, lipids and glutamine. The intracellular sites of oxygen consumption-coupled ATP production are the mitochondria, double-membraned organelles that provide a dynamic and multifaceted role in cell signalling and metabolism. Highly evolutionarily conserved molecular mechanisms exist to sense and respond to changes in cellular oxygen levels. The primary transcriptional regulators of the response to decreased oxygen levels (hypoxia) are the hypoxia-inducible factors (HIFs), which play important roles in both physiological and pathophysiological contexts. In this review we explore the relationship between HIF-regulated signalling pathways and the mitochondria, including the regulation of mitochondrial metabolism, biogenesis and distribution.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherBirkhauser Verlag
dc.subjectMitochondriaen
dc.subjectHumansen
dc.subjectOxygenen
dc.subjectReactive Oxygen Speciesen
dc.subjectAdenosine Triphosphateen
dc.subjectSignal Transductionen
dc.subjectCell Hypoxiaen
dc.subjectElectron Transporten
dc.subjectEnergy Metabolismen
dc.subjectOxygen Consumptionen
dc.subjectHypoxia-Inducible Factor 1, alpha Subuniten
dc.titleExploring the molecular interface between hypoxia-inducible factor signalling and mitochondria.en
dc.typeArticle
prism.endingPage1777
prism.issueIdentifier9en
prism.publicationDate2019en
prism.publicationNameCellular and molecular life sciences : CMLSen
prism.startingPage1759
prism.volume76en
dc.identifier.doi10.17863/CAM.36733
dcterms.dateAccepted2019-02-01en
rioxxterms.versionofrecord10.1007/s00018-019-03039-yen
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-05en
dc.contributor.orcidAshcroft, Margaret [0000-0002-0066-3707]
dc.identifier.eissn1420-9071
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/K002201/2)
cam.orpheus.successThu Jan 30 10:51:00 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-05-31


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