Changes in plasma phospholipid fatty acid profiles over 13 years and correlates of change: European Prospective Investigation into Cancer and Nutrition-Norfolk Study.
The American journal of clinical nutrition
American Society for Clinical Nutrition, Inc.
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Zheng, J., Imamura, F., Sharp, S., Koulman, A., Griffin, J., Mulligan, A., Luben, R., et al. (2019). Changes in plasma phospholipid fatty acid profiles over 13 years and correlates of change: European Prospective Investigation into Cancer and Nutrition-Norfolk Study.. The American journal of clinical nutrition, 109 (6), 1527-1534. https://doi.org/10.1093/ajcn/nqz030
Abstract Background: Little is known about changes in blood fatty acid compositions over time and the correlates of any changes in a general population. Objective: We aimed to estimate changes in 27 individual plasma phospholipid fatty acids and fatty acid groups over time, and to identify potential correlates of these changes. Design: Plasma phospholipid fatty acids were profiled at three time-points (1993-1997, 1998-2000, 2004-2011) among 722 participants in the European Prospective Investigation into Cancer and Nutrition-Norfolk Study, UK. Linear regression models were used to estimate both (1) average changes over time in 27 individual fatty acids and 8 pre-specified fatty acid groups and (2) associations of changes in dietary and lifestyle factors with changes in the 8 fatty acid groups, mutually adjusted for dietary/lifestyle factors and other confounders. The pre-specified fatty acid groups were odd-chain saturated fatty acids (SFAs), even-chain SFAs, very-long-chain SFAs, marine n-3 polyunsaturated fatty acids (PUFAs), plant n-3 PUFA, n-6 PUFAs, monounsaturated fatty acids (MUFAs) and trans fatty acids (TFAs). Results: Adjusted for confounders, fatty acid concentrations decreased for odd-chain SFAs (annual % difference in mol%: -0.63%), even-chain SFAs (-0.05%), n-6 PUFAs (-0.25%) and TFAs (-7.84%). In contrast, concentrations increased for marine n-3 PUFAs (1.28%) and MUFAs (0.45%) but there were no changes in very-long-chain SFAs or plant n-3 PUFA. Changes in fatty acid levels were associated with consumption of different food groups. For example, an average 100 g/day increase in fatty fish intake was associated with a 19.3% greater annual increase in marine n-3 PUFAs. Conclusions: Even-chain SFAs and TFAs declined and marine n-3 PUFAs increased over time. These changes were partially explained by changes in dietary habits, and could potentially help interpret associations of baseline fatty acid composition with future disease risk.
Humans, Fatty Acids, Phospholipids, Diet, Nutrition Surveys, Prospective Studies, Feeding Behavior, Adult, Aged, Middle Aged, Europe, Female, Male
Medical Research Council Epidemiology Unit MC_UU_12015/1 and MC_UU_12015/5; Medical Research Council Human Nutrition Research MC_UP_A090_1006; Cambridge Lipidomics Biomarker Research Initiative G0800783; NIHR Biomedical Research Centre Cambridge: Nutrition, Diet, and Lifestyle Research Theme (IS-BRC-1215-20014). Dr Ju-Sheng Zheng has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 701708.
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (701708)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
MEDICAL RESEARCH COUNCIL (MR/N003284/1)
Medical Research Council (MC_PC_13030)
Biotechnology and Biological Sciences Research Council (BB/M027252/1)
External DOI: https://doi.org/10.1093/ajcn/nqz030
This record's URL: https://www.repository.cam.ac.uk/handle/1810/289510