Combined Antioxidant and Glucocorticoid Therapy for Safer Treatment of Preterm Birth.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
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Authors
Garrud, Tessa AC
Giussani, Dino A
Abstract
Ante- and postnatal glucocorticoid therapy reduces morbidity and mortality in the preterm infant, and it is therefore one of the best examples of the successful translation of basic experimental science into human clinical practice. However, accruing evidence derived from human clinical studies and from experimental studies in animal models raise serious concerns about potential long-term adverse effects of treatment on growth and neurological and cardiovascular function in the offspring. This review explores whether combined antioxidant and glucocorticoid therapy may be safer than glucocorticoid therapy alone for the treatment of preterm birth.
Description
Keywords
Animals, Antioxidants, Drug-Related Side Effects and Adverse Reactions, Female, Glucocorticoids, Humans, Infant, Premature, Diseases, Oxidative Stress, Pregnancy, Premature Birth
Journal Title
Trends Endocrinol Metab
Conference Name
Journal ISSN
1043-2760
1879-3061
1879-3061
Volume Title
30
Publisher
Elsevier BV
Publisher DOI
Sponsorship
British Heart Foundation (None)
British Heart Foundation (None)
Wellcome Trust (089941/Z/09/A)
British Heart Foundation (RG/17/8/32924)
Lister Institute of Preventive Medicine (unknown)
British Heart Foundation (None)
Wellcome Trust (089941/Z/09/A)
British Heart Foundation (RG/17/8/32924)
Lister Institute of Preventive Medicine (unknown)
The British Heart Foundation and The Wellcome Trust