Combined Antioxidant and Glucocorticoid Therapy for Safer Treatment of Preterm Birth.
Garrud, Tessa AC
Trends in endocrinology and metabolism: TEM
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Garrud, T. A., & Giussani, D. (2019). Combined Antioxidant and Glucocorticoid Therapy for Safer Treatment of Preterm Birth.. Trends in endocrinology and metabolism: TEM, 30 (4), 258-269. https://doi.org/10.1016/j.tem.2019.02.003
• Synthetic glucocorticoids are routinely administered during the perinatal period in instances of pre-term birth. Despite clear life-saving beneficial effects, growing evidence suggests long-term detrimental consequences for the offspring growth, brain and cardiovascular development. • If we can better understand the physiological mechanisms resulting in these adverse side effects of synthetic glucocorticoids, we could fine-tune current clinical treatment to minimise adverse side-effects whilst maintaining the clinical benefits. • Combined antioxidant and glucocorticoid therapy may be safer for the treatment of preterm birth and the hypothesis the Giussani laboratory proposes needs to be tested in human clinical trials.
Animals, Humans, Premature Birth, Infant, Premature, Diseases, Glucocorticoids, Antioxidants, Oxidative Stress, Pregnancy, Female, Drug-Related Side Effects and Adverse Reactions
The British Heart Foundation and The Wellcome Trust
British Heart Foundation (RG/11/16/29260)
British Heart Foundation (FS/12/74/29778)
Wellcome Trust (089941/Z/09/A)
British Heart Foundation (RG/17/8/32924)
Lister Institute of Preventive Medicine (unknown)
External DOI: https://doi.org/10.1016/j.tem.2019.02.003
This record's URL: https://www.repository.cam.ac.uk/handle/1810/289511