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dc.contributor.authorMarklund, Matti
dc.contributor.authorWu, Jason HY
dc.contributor.authorImamura, Fumiaki
dc.contributor.authorDel Gobbo, Liana C
dc.contributor.authorFretts, Amanda
dc.contributor.authorde Goede, Janette
dc.contributor.authorShi, Peilin
dc.contributor.authorTintle, Nathan
dc.contributor.authorWennberg, Maria
dc.contributor.authorAslibekyan, Stella
dc.contributor.authorChen, Tzu-An
dc.contributor.authorde Oliveira Otto, Marcia C
dc.contributor.authorHirakawa, Yoichiro
dc.contributor.authorEriksen, Helle Højmark
dc.contributor.authorKröger, Janine
dc.contributor.authorLaguzzi, Federica
dc.contributor.authorLankinen, Maria
dc.contributor.authorMurphy, Rachel A
dc.contributor.authorPrem, Kiesha
dc.contributor.authorSamieri, Cécilia
dc.contributor.authorVirtanen, Jyrki
dc.contributor.authorWood, Alexis C
dc.contributor.authorWong, Kerry
dc.contributor.authorYang, Wei-Sin
dc.contributor.authorZhou, Xia
dc.contributor.authorBaylin, Ana
dc.contributor.authorBoer, Jolanda MA
dc.contributor.authorBrouwer, Ingeborg A
dc.contributor.authorCampos, Hannia
dc.contributor.authorChaves, Paulo HM
dc.contributor.authorChien, Kuo-Liong
dc.contributor.authorde Faire, Ulf
dc.contributor.authorDjoussé, Luc
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorEl-Abbadi, Naglaa
dc.contributor.authorForouhi, Nita
dc.contributor.authorMichael Gaziano, J
dc.contributor.authorGeleijnse, Johanna M
dc.contributor.authorGigante, Bruna
dc.contributor.authorGiles, Graham
dc.contributor.authorGuallar, Eliseo
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHarris, Tamara
dc.contributor.authorHarris, William S
dc.contributor.authorHelmer, Catherine
dc.contributor.authorHellenius, Mai-Lis
dc.contributor.authorHodge, Allison
dc.contributor.authorHu, Frank B
dc.contributor.authorJacques, Paul F
dc.contributor.authorJansson, Jan-Håkan
dc.contributor.authorKalsbeek, Anya
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorKoh, Woon-Puay
dc.contributor.authorLaakso, Markku
dc.contributor.authorLeander, Karin
dc.contributor.authorLin, Hung-Ju
dc.contributor.authorLind, Lars
dc.contributor.authorLuben, Robert
dc.contributor.authorLuo, Juhua
dc.contributor.authorMcKnight, Barbara
dc.contributor.authorMursu, Jaakko
dc.contributor.authorNinomiya, Toshiharu
dc.contributor.authorOvervad, Kim
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorRimm, Eric
dc.contributor.authorSchulze, Matthias B
dc.contributor.authorSiscovick, David
dc.contributor.authorSkjelbo Nielsen, Michael
dc.contributor.authorSmith, Albert V
dc.contributor.authorSteffen, Brian T
dc.contributor.authorSteffen, Lyn
dc.contributor.authorSun, Qi
dc.contributor.authorSundström, Johan
dc.contributor.authorTsai, Michael Y
dc.contributor.authorTunstall-Pedoe, Hugh
dc.contributor.authorUusitupa, Matti IJ
dc.contributor.authorvan Dam, Rob M
dc.contributor.authorVeenstra, Jenna
dc.contributor.authorMonique Verschuren, WM
dc.contributor.authorWareham, Nicholas
dc.contributor.authorWillett, Walter
dc.contributor.authorWoodward, Mark
dc.contributor.authorYuan, Jian-Min
dc.contributor.authorMicha, Renata
dc.contributor.authorLemaitre, Rozenn N
dc.contributor.authorMozaffarian, Dariush
dc.contributor.authorRisérus, Ulf
dc.contributor.authorCohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCE)
dc.date.accessioned2019-02-19T00:30:41Z
dc.date.available2019-02-19T00:30:41Z
dc.date.issued2019-05-21
dc.identifier.issn0009-7322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/289590
dc.description.abstractBACKGROUND: Global dietary recommendations for and cardiovascular effects of linoleic acid, the major dietary omega-6 fatty acid, and its major metabolite, arachidonic acid, remain controversial. To address this uncertainty and inform international recommendations, we evaluated how in vivo circulating and tissue levels of linoleic acid (LA) and arachidonic acid (AA) relate to incident cardiovascular disease (CVD) across multiple international studies. METHODS: We performed harmonized, de novo, individual-level analyses in a global consortium of 30 prospective observational studies from 13 countries. Multivariable-adjusted associations of circulating and adipose tissue LA and AA biomarkers with incident total CVD and subtypes (coronary heart disease, ischemic stroke, cardiovascular mortality) were investigated according to a prespecified analytic plan. Levels of LA and AA, measured as the percentage of total fatty acids, were evaluated linearly according to their interquintile range (ie, the range between the midpoint of the first and fifth quintiles), and categorically by quintiles. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Heterogeneity was explored by age, sex, race, diabetes mellitus, statin use, aspirin use, omega-3 levels, and fatty acid desaturase 1 genotype (when available). RESULTS: In 30 prospective studies with medians of follow-up ranging 2.5 to 31.9 years, 15 198 incident cardiovascular events occurred among 68 659 participants. Higher levels of LA were significantly associated with lower risks of total CVD, cardiovascular mortality, and ischemic stroke, with hazard ratios per interquintile range of 0.93 (95% CI, 0.88-0.99), 0.78 (0.70-0.85), and 0.88 (0.79-0.98), respectively, and nonsignificantly with lower coronary heart disease risk (0.94; 0.88-1.00). Relationships were similar for LA evaluated across quintiles. AA levels were not associated with higher risk of cardiovascular outcomes; in a comparison of extreme quintiles, higher levels were associated with lower risk of total CVD (0.92; 0.86-0.99). No consistent heterogeneity by population subgroups was identified in the observed relationships. CONCLUSIONS: In pooled global analyses, higher in vivo circulating and tissue levels of LA and possibly AA were associated with lower risk of major cardiovascular events. These results support a favorable role for LA in CVD prevention.
dc.description.sponsorshipIn supplementary material: Drs Imamura, Forouhi and Wareham acknowledge support from the core Medical Research Council Epidemiology Unit Programmes (MC_UU_12015/1 and MC_UU_12015/5).
dc.format.mediumPrint
dc.languageeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.subjectCohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCE)
dc.subjectHumans
dc.subjectCardiovascular Diseases
dc.subjectDietary Fats
dc.subjectArachidonic Acid
dc.subjectLinoleic Acid
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectRisk Reduction Behavior
dc.subjectPrimary Prevention
dc.subjectNutritive Value
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectRecommended Dietary Allowances
dc.subjectProtective Factors
dc.subjectBiomarkers
dc.subjectObservational Studies as Topic
dc.subjectDiet, Healthy
dc.titleBiomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality.
dc.typeArticle
prism.endingPage2436
prism.issueIdentifier21
prism.publicationDate2019
prism.publicationNameCirculation
prism.startingPage2422
prism.volume139
dc.identifier.doi10.17863/CAM.36839
dcterms.dateAccepted2019-02-07
rioxxterms.versionofrecord10.1161/CIRCULATIONAHA.118.038908
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-05
dc.contributor.orcidImamura, Fumiaki [0000-0002-6841-8396]
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.contributor.orcidLuben, Robert [0000-0002-5088-6343]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.identifier.eissn1524-4539
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/5)
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idMedical Research Council (G1000143)
pubs.funder-project-idMedical Research Council (G0401527)
pubs.funder-project-idMedical Research Council (MR/N003284/1)
cam.orpheus.successThu Jan 30 10:50:41 GMT 2020 - Embargo updated
rioxxterms.freetoread.startdate2019-11-30


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