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The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Braithwaite, Vickie S  ORCID logo  https://orcid.org/0000-0002-3366-2903
D'Angelo, Stefania 
Prentice, Ann 

Abstract

Iron and vitamin D deficiencies are common during pregnancy. Our aim was to identify whether antenatal vitamin D₃ supplementation affects iron status (via hepcidin suppression) and/or inflammation. Using a subset of the UK multicenter Maternal Vitamin D Osteoporosis Study (MAVIDOS)-a double-blinded, randomized, placebo-controlled trial (ISRCTN82927713; EudraCT2007-001716-23)-we performed a secondary laboratory analysis. Women with blood samples from early and late pregnancy (vitamin D₃ (1000 IU/day from ~14 weeks gestation n = 93; placebo n = 102) who gave birth in the springtime (March⁻May) were selected as we anticipated seeing the greatest treatment group difference in change in 25-hydroxyvitamin D (25OHD) concentration. Outcomes were hepcidin, ferritin, C-reactive protein, and α1-acid glycoprotein concentration in late pregnancy (25OHD concentration was measured previously). By late pregnancy, 25OHD concentration increased by 17 nmol/L in the vitamin D₃ group and decreased by 11 nmol/L in the placebo group; hepcidin, ferritin, and inflammatory markers decreased but no treatment group differences were seen. In late pregnancy, positive relationships between 25OHD and hepcidin and 25OHD and ferritin in the placebo group were observed but not in the treatment group (group × 25OHD interaction, p < 0.02). Vitamin D₃ supplementation had no effect on hepcidin, ferritin, or inflammatory status suggesting no adjunctive value of vitamin D₃ in reducing rates of antenatal iron deficiency.

Description

Keywords

C-reactive protein, Vitamin D, ferritin, hepcidin, inflammation, pregnancy, Adult, Anemia, Iron-Deficiency, C-Reactive Protein, Cholecalciferol, Dietary Supplements, Double-Blind Method, Female, Ferritins, Hepcidins, Humans, Inflammation, Iron, Nutritional Status, Pregnancy, Pregnancy Complications, Pregnancy Trimesters, Seasons, Vitamin D, Vitamin D Deficiency, Young Adult

Journal Title

Nutrients

Conference Name

Journal ISSN

2072-6643
2072-6643

Volume Title

11

Publisher

MDPI AG
Sponsorship
European Commission (289346)
Medical Research Council (MC_U105960371)