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dc.contributor.authorBalasubramanian, Ruchita
dc.contributor.authorIm, Justin
dc.contributor.authorLee, Jung-Seok
dc.contributor.authorJeon, Hyon Jin
dc.contributor.authorMogeni, Ondari D
dc.contributor.authorKim, Jerome H
dc.contributor.authorRakotozandrindrainy, Raphaël
dc.contributor.authorBaker, Stephen
dc.contributor.authorMarks, Florian
dc.date.accessioned2019-02-20T00:30:32Z
dc.date.available2019-02-20T00:30:32Z
dc.date.issued2019
dc.identifier.issn2164-5515
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/289682
dc.description.abstractInvasive non-typhoidal Salmonella (iNTS) disease has emerged as a major public health concern. Yet, understanding of the global burden is incomplete, limited particularly by the breadth of blood culture-based surveillance systems that are able to accurately diagnose the etiology of bacteremia. The accessibility of whole genome sequencing has allowed for genetic characterization of pathogens, shedding light on its evolutionary history and sounding alerts for its future progression. iNTS disease is observed to be a particular threat in sub-Saharan Africa, with a case fatality rate greatly exceeding that of typhoid fever, and commonly affecting infants, young children and immunocompromised adults. While iNTS disease might also be a threat in Asia and Latin America, its burden is not well characterized, primarily owing to the lack of comprehensive reporting in these regions. Drug-resistant Salmonella enterica (S. enterica) serovars (e.g. Typhimurium sequence type 313 (ST313)) have emerged as a potential consequence of sustained antibiotic pressure. Genetic analyses have identified distinguished iNTS disease-causing strains that are particularly virulent in certain human host populations. Effective treatment strategies, including vaccination, are necessary; iNTS vaccines targeting the most common S. enterica serovars, Typhimurium, Enteritidis and Dublin, are currently in early developmental stages. Funding and political support is needed to promote vaccine development and implementation programs to ultimately reduce the threat of iNTS disease in high risk areas.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherInforma UK Limited
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectSalmonella enterica
dc.subjectBacteremia
dc.subjectSalmonella Infections
dc.subjectSalmonella Vaccines
dc.subjectAnti-Bacterial Agents
dc.subjectVaccination
dc.subjectDrug Resistance, Bacterial
dc.subjectImmunocompromised Host
dc.subjectCost of Illness
dc.subjectGlobal Health
dc.subjectWhole Genome Sequencing
dc.titleThe global burden and epidemiology of invasive non-typhoidal Salmonella infections.
dc.typeArticle
prism.endingPage1426
prism.issueIdentifier6
prism.publicationDate2019
prism.publicationNameHum Vaccin Immunother
prism.startingPage1421
prism.volume15
dc.identifier.doi10.17863/CAM.36930
rioxxterms.versionofrecord10.1080/21645515.2018.1504717
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-01
dc.contributor.orcidBalasubramanian, Ruchita [0000-0002-9151-9873]
dc.contributor.orcidLee, Jung-Seok [0000-0002-1038-8948]
dc.contributor.orcidJeon, Hyon Jin [0000-0002-2344-4574]
dc.contributor.orcidMogeni, Ondari D [0000-0001-5133-3735]
dc.contributor.orcidKim, Jerome H [0000-0003-0461-6438]
dc.contributor.orcidBaker, Stephen [0000-0003-1308-5755]
dc.contributor.orcidMarks, Florian [0000-0002-6043-7170]
dc.identifier.eissn2164-554X
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-09-05


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International