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dc.contributor.authorInternational Typhoid Consortium,en
dc.contributor.authorWong, Vanessaen
dc.contributor.authorHolt, Kathryn Een
dc.contributor.authorOkoro, Chinyereen
dc.contributor.authorBaker, Stephenen
dc.contributor.authorPickard, Derek Jen
dc.contributor.authorMarks, Florianen
dc.contributor.authorPage, Andrew Jen
dc.contributor.authorOlanipekun, Graceen
dc.contributor.authorMunir, Hudaen
dc.contributor.authorAlter, Roxanneen
dc.contributor.authorFey, Paul Den
dc.contributor.authorFeasey, Nicholas Aen
dc.contributor.authorWeill, Francois-Xavieren
dc.contributor.authorLe Hello, Simonen
dc.contributor.authorHart, Peter Jen
dc.contributor.authorKariuki, Samuelen
dc.contributor.authorBreiman, Robert Fen
dc.contributor.authorGordon, Melita Aen
dc.contributor.authorHeyderman, Robert Sen
dc.contributor.authorJacobs, Janen
dc.contributor.authorLunguya, Octavieen
dc.contributor.authorMsefula, Chisomoen
dc.contributor.authorMacLennan, Calman Aen
dc.contributor.authorKeddy, Karen Hen
dc.contributor.authorSmith, Anthony Men
dc.contributor.authorOnsare, Robert Sen
dc.contributor.authorDe Pinna, Elizabethen
dc.contributor.authorNair, Satheeshen
dc.contributor.authorAmos, Benen
dc.contributor.authorDougan, Gordonen
dc.contributor.authorObaro, Stephenen
dc.date.accessioned2019-02-20T00:30:41Z
dc.date.available2019-02-20T00:30:41Z
dc.date.issued2016-09-22en
dc.identifier.issn1935-2727
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/289690
dc.description.abstractBACKGROUND: The burden of typhoid in sub-Saharan African (SSA) countries has been difficult to estimate, in part, due to suboptimal laboratory diagnostics. However, surveillance blood cultures at two sites in Nigeria have identified typhoid associated with Salmonella enterica serovar Typhi (S. Typhi) as an important cause of bacteremia in children. METHODS: A total of 128 S. Typhi isolates from these studies in Nigeria were whole-genome sequenced, and the resulting data was used to place these Nigerian isolates into a worldwide context based on their phylogeny and carriage of molecular determinants of antibiotic resistance. RESULTS: Several distinct S. Typhi genotypes were identified in Nigeria that were related to other clusters of S. Typhi isolates from north, west and central regions of Africa. The rapidly expanding S. Typhi clade 4.3.1 (H58) previously associated with multiple antimicrobial resistances in Asia and in east, central and southern Africa, was not detected in this study. However, antimicrobial resistance was common amongst the Nigerian isolates and was associated with several plasmids, including the IncHI1 plasmid commonly associated with S. Typhi. CONCLUSIONS: These data indicate that typhoid in Nigeria was established through multiple independent introductions into the country, with evidence of regional spread. MDR typhoid appears to be evolving independently of the haplotype H58 found in other typhoid endemic countries. This study highlights an urgent need for routine surveillance to monitor the epidemiology of typhoid and evolution of antimicrobial resistance within the bacterial population as a means to facilitate public health interventions to reduce the substantial morbidity and mortality of typhoid.
dc.format.mediumElectronic-eCollectionen
dc.languageengen
dc.rightsCC0 No rights reserved
dc.rights.uri
dc.subjectInternational Typhoid Consortiumen
dc.titleMolecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa.en
dc.typeArticle
prism.issueIdentifier9en
prism.publicationDate2016en
prism.publicationNamePLoS neglected tropical diseasesen
prism.startingPagee0004781
prism.volume10en
dc.identifier.doi10.17863/CAM.36938
dcterms.dateAccepted2016-05-25en
rioxxterms.versionofrecord10.1371/journal.pntd.0004781en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-09-22en
dc.contributor.orcidHolt, Kathryn E [0000-0003-3949-2471]
dc.contributor.orcidMarks, Florian [0000-0002-6043-7170]
dc.contributor.orcidFeasey, Nicholas A [0000-0003-4041-1405]
dc.contributor.orcidWeill, Francois-Xavier [0000-0001-9941-5799]
dc.contributor.orcidLe Hello, Simon [0000-0001-7993-4305]
dc.contributor.orcidGordon, Melita A [0000-0002-0629-0884]
dc.contributor.orcidHeyderman, Robert S [0000-0003-4573-449X]
dc.contributor.orcidKeddy, Karen H [0000-0001-8640-2235]
dc.contributor.orcidNair, Satheesh [0000-0002-7297-1485]
dc.contributor.orcidAmos, Ben [0000-0002-8569-1650]
dc.contributor.orcidDougan, Gordon [0000-0003-0022-965X]
dc.identifier.eissn1935-2735
rioxxterms.typeJournal Article/Reviewen


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