Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity.
Sueiro, Aurelio M
Casanueva, Felipe F
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Barrachina, M. N., Izquierdo, I., Hermida-Nogueira, L., Sueiro, A. M., Guitián, E., Casanueva, F. F., Farndale, R., et al. (2019). Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity.. Data in brief, 23 103784. https://doi.org/10.1016/j.dib.2019.103784
Abstract This data article is associated with the manuscript “GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity” . The study refers to a combination of different approaches in order to identify platelet-derived biomarkers in obesity. A total of 34 obese patients and their lean-matched controls were included in the study. We carried out a proteomic and functional (aggregation assays) analysis to find alterations in platelet-derived signalling pathways. After that, biochemical and mechanistic (flow cytometry assays) approaches were done in order to confirm a hyperactivation of the GPVI-related signalling pathway.
Spanish Ministry of Economy and Competitiveness (MINECO) [grant No. SAF2016-79662-R] European Regional Development Fund (ERDF). Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia (Centro Singular de investigación de Galicia accreditation 2016-2019, ED431G/05) European Regional Development Fund (ERDF) British Heart Foundation, grants SP/13/7/30575, PG/18/36/338, and RG/15/4/31268.
British Heart Foundation (PG/18/36/33811)
British Heart Foundation (RG/15/4/31268)
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External DOI: https://doi.org/10.1016/j.dib.2019.103784
This record's URL: https://www.repository.cam.ac.uk/handle/1810/289834