Association between developmental milestones and age of schizophrenia onset: Results from the Northern Finland Birth Cohort 1966.
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Authors
Whittier, Anjalene
Wagner, Adam P
Veijola, Juha
Jääskeläinen, Erika
Miettunen, Jouko
Publication Date
2019-06Journal Title
Schizophrenia research
ISSN
0920-9964
Publisher
Elsevier BV
Volume
208
Pages
228-234
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Stochl, J., Whittier, A., Wagner, A. P., Veijola, J., Jääskeläinen, E., Miettunen, J., Khandaker, G., & et al. (2019). Association between developmental milestones and age of schizophrenia onset: Results from the Northern Finland Birth Cohort 1966.. Schizophrenia research, 208 228-234. https://doi.org/10.1016/j.schres.2019.02.013
Abstract
We investigated relationships between early developmental
milestones, schizophrenia incidence and variability in its age at onset.
We hypothesised that the period of risk for schizophrenia would be longer
for those with later development. The Northern Finland Birth Cohort 1966
was followed until 47 years of age, and those members diagnosed with
schizophrenia or any other non-affective psychoses identified. Latent
profile analysis was used to classify people into homogenous classes with
respect to developmental milestones, and subsequently survival analysis
explored relationship between classes and age of schizophrenia onset.
Results suggest that 4-classes (early, regular, late, and extra late
developers) can be identified, but due to few cases in one class (n=93,
<0.01% of 10 501), only 3 classes (early, regular, late) could be
meaningfully compared. Schizophrenia incidence until 47 years of age
differed systematically between classes: late developers had the highest
cumulative incidence (2.39%); regular were intermediate (1.25%); and
early developers had the lowest incidence (0.99%). However, age at onset
and its variability was similar across classes, suggesting that our
hypothesis of a wider 'window' for schizophrenia onset in late developers
was not supported.
Keywords
Humans, Incidence, Cohort Studies, Developmental Disabilities, Schizophrenia, Age of Onset, Middle Aged, Finland, Female, Male
Sponsorship
National Institute for Health Research (NIHR) (via Cambridgeshire and Peterborough NHS Foundation Trust (CPFT) (NF-SI-0514-10117)
Wellcome Trust (201486/Z/16/Z)
Cambridge University Hospitals NHS Foundation Trust (CUH) (BRC 2012-2017)
MRC (MC_PC_17213)
Identifiers
External DOI: https://doi.org/10.1016/j.schres.2019.02.013
This record's URL: https://www.repository.cam.ac.uk/handle/1810/289861
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