Chasing the "Holy Grail": Modulating Neutrophils in Inflammatory Lung Disease.
American journal of respiratory and critical care medicine
American Thoracic Society
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Summers, C. (2019). Chasing the "Holy Grail": Modulating Neutrophils in Inflammatory Lung Disease.. American journal of respiratory and critical care medicine, 200 (2), 131-132. https://doi.org/10.1164/rccm.201902-0333ed
Acute respiratory distress syndrome (ARDS) is devastating condition characterized by severe hypoxemia, the accumulation of non-cardiogenic pulmonary edema and lung inflammation. ARDS affects >10% of all patients to admitted to Intensive Care Units worldwide, of whom 35-45% die , predominantly of multi-organ failure. Survivors of ARDS are often left with significant long-term morbidities, and the healthcare costs associated with ARDS even years 3-5 after diagnosis matching those of chronic conditions such as cardiac failure and chronic obstructive pulmonary disease . Despite decades of research, and many clinical trials, there remains no effective pharmacotherapy for ARDS.
Neutrophils, Humans, Acute Lung Injury, Hypoxia
External DOI: https://doi.org/10.1164/rccm.201902-0333ed
This record's URL: https://www.repository.cam.ac.uk/handle/1810/289889