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dc.contributor.authorRothen, Nicolas
dc.contributor.authorSchwartzman, David J
dc.contributor.authorBor, Daniel
dc.contributor.authorSeth, Anil K
dc.date.accessioned2019-02-27T15:59:12Z
dc.date.available2019-02-27T15:59:12Z
dc.date.issued2018-03
dc.identifier.issn0028-3932
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/290036
dc.description.abstractSynesthesia is associated with additional perceptual experiences, which are automatically and consistently triggered by specific inducing stimuli. Synesthesia is also accompanied by more general sensory and cortical changes, including enhanced modality-specific cortical excitability. Extensive cognitive training has been shown to generate synesthesia-like phenomenology but whether these experiences are accompanied by neurophysiological changes characteristic of synesthesia remains unknown. Addressing this question provides a unique opportunity to elucidate the neural basis of perceptual plasticity relevant to conscious experiences. Here we investigate whether extensive training of letter-color associations leads not only to synesthetic experiences, but also to changes in cortical excitability. We confirm that overtraining synesthetic associations results in synesthetic phenomenology. Stroop tasks further reveal synesthesia-like performance following training. Electroencephalography and transcranial magnetic stimulation show, respectively, enhanced visual evoked potentials (in response to untrained patterns) and lower phosphene thresholds, demonstrating specific cortical changes. An active (using letter-symbol training) and a passive control confirmed these results were due to letter-color training and not simply to repeated testing. Summarizing, we demonstrate specific cortical changes, following training-induced acquisition of synesthetic phenomenology that are characteristic of genuine synesthesia. Collectively, our data reveal dramatic plasticity in human visual perception, expressed through a coordinated set of behavioral, neurophysiological, and phenomenological changes.
dc.description.sponsorshipThis work was supported by the Dr. Mortimer and Theresa Sackler Foundation, which supports the Sackler Centre for Consciousness Science, by the Swiss National Science Foundation (Grant Number PZ00P1_154954), which supports Nicolas Rothen, and by the Daphne Jackson Trust and the Biotechnology and Biological Sciences Research Council (BBSRC), which supports Daniel Bor.
dc.languageeng
dc.publisherElsevier
dc.subjectCortical excitability
dc.subjectCortical plasticity
dc.subjectElectroencephalogram (EEG)
dc.subjectPerceptual processing
dc.subjectTranscranial magnetic stimulation (TMS)
dc.subjectAssociation
dc.subjectCerebral Cortex
dc.subjectColor
dc.subjectElectroencephalography
dc.subjectEvoked Potentials, Visual
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectNeuronal Plasticity
dc.subjectPerceptual Disorders
dc.subjectReading
dc.subjectTranscranial Magnetic Stimulation
dc.subjectVisual Perception
dc.subjectYoung Adult
dc.titleCoordinated neural, behavioral, and phenomenological changes in perceptual plasticity through overtraining of synesthetic associations.
dc.typeArticle
prism.endingPage162
prism.publicationDate2018
prism.publicationNameNeuropsychologia
prism.startingPage151
prism.volume111
dc.identifier.doi10.17863/CAM.37261
dcterms.dateAccepted2018-01-19
rioxxterms.versionofrecord10.1016/j.neuropsychologia.2018.01.030
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.licenseref.startdate2018-03
dc.contributor.orcidBor, Daniel [0000-0002-0741-8157]
dc.identifier.eissn1873-3514
dc.publisher.urlhttps://www.sciencedirect.com/science/article/pii/S0028393218300368?via%3Dihub#!
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-01-31
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0028393218300368?via%3Dihub#!
rioxxterms.freetoread.startdate2019-01-31


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