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Mobilising vitamin D from adipose tissue: The potential impact of exercise.

Published version
Peer-reviewed

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Type

Article

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Authors

Hengist, A 
Perkin, O 
Gonzalez, JT 
Betts, JA 
Hewison, M 

Abstract

Vitamin D is lipophilic and accumulates substantially in adipose tissue. Even without supplementation, the amount of vitamin D in the adipose of a typical adult is equivalent to several months of the daily reference nutrient intake (RNI). Paradoxically, despite the large amounts of vitamin D located in adipose tissue, individuals with obesity are often vitamin D deficient according to consensus measures of vitamin D status (serum 25-hydroxyvitamin D concentrations). Thus, it appears that vitamin D can become 'trapped' in adipose tissue, potentially due to insufficient lipolytic stimulation and/or due to tissue dysfunction/adaptation resulting from adipose expansion. Emerging evidence suggests that exercise may mobilise vitamin D from adipose (even in the absence of weight loss). If exercise helps to mobilise vitamin D from adipose tissue, then this could have important ramifications for practitioners and policymakers regarding the management of low circulating levels of vitamin D, as well as chronically low levels of physical activity, obesity and associated health conditions. This perspective led us to design a study to examine the impact of exercise on vitamin D status, vitamin D turnover and adipose tissue vitamin D content (the VitaDEx project). The VitaDEx project will determine whether increasing physical activity (via exercise) represents a potentially useful strategy to mobilise vitamin D from adipose tissue.

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Keywords

25(OH)D, 25‐hydroxyvitamin D, adipose, exercise, physical activity, vitamin D

Journal Title

Nutr Bull

Conference Name

Journal ISSN

1471-9827
1467-3010

Volume Title

44

Publisher

Wiley
Sponsorship
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
National Institute for Health and Care Research (IS-BRC-1215-20014)
Biotechnology and Biological Sciences Research Council (BB/R018928/1)
BBSRC (BB/R018928/1)