Innovative methods for improving cognition, motivation and wellbeing in schizophrenia.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Sahakian, Barbara J
Savulich, George
Abstract
Neuropsychiatric disorders involve impairment of cognition, motivation and their interaction1. Cognitive manifestations include attentional biases, aberrant learning, dysfunctional reward, and lack of top-down cognitive control by the prefrontal cortex. These cognitive manifestations are both “cold” or non-emotional and “hot” or social and emotional2. From a neurobiological perspective, these relate to two partially segregated loops: the “cold” loop including the dorsal lateral prefrontal cortex and the “hot” affective loop including the orbitofrontal cortex and the ventral striatum, with strong connections to the “emotional brain” including the amygdala2.
Description
Keywords
4203 Health Services and Systems, 32 Biomedical and Clinical Sciences, 3202 Clinical Sciences, 42 Health Sciences
Journal Title
World Psychiatry
Conference Name
Journal ISSN
1723-8617
2051-5545
2051-5545
Volume Title
18
Publisher
Wiley
Publisher DOI
Sponsorship
National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (Mental Health Theme)