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dc.contributor.authorGrabenhorst, Fabianen
dc.contributor.authorBáez-Mendoza, Raymundoen
dc.contributor.authorGenest, Wilfrieden
dc.contributor.authorDeco, Gustavoen
dc.contributor.authorSchultz, Wolframen
dc.date.accessioned2019-03-05T00:30:48Z
dc.date.available2019-03-05T00:30:48Z
dc.date.issued2019-05en
dc.identifier.issn0092-8674
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/290174
dc.description.abstractBy observing their social partners, primates learn about reward values of objects. Here we show that monkeys’ amygdala neurons derive object values from observation and use these values to simulate a partner monkey’s decision process. While monkeys alternated making reward-based choices, amygdala neurons encoded object-specific values learned from observation. Dynamic activities converted these values to representations of the recorded monkey’s own choices. Surprisingly, the same activity patterns unfolded spontaneously before partner’s choices in separate neurons, as if these neurons simulated the partner’s decision-making. These ‘simulation neurons’ encoded signatures of mutual-inhibitory decision computation, including value comparisons and value-to-choice conversions, resulting in accurate predictions of partner’s choices. Population decoding identified differential contributions of amygdala subnuclei. Biophysical modelling of amygdala circuits showed that simulation neurons emerge naturally from convergence between object-value neurons and self-other neurons. By simulating decision computations during observation, these neurons could allow primates to reconstruct their social partners’ mental states.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherCell Press
dc.subjectAmygdalaen
dc.subjectNeuronsen
dc.subjectAnimalsen
dc.subjectMacaca mulattaen
dc.subjectBehavior, Animalen
dc.subjectInterpersonal Relationsen
dc.subjectLearningen
dc.subjectRewarden
dc.subjectDecision Makingen
dc.subjectChoice Behavioren
dc.subjectMaleen
dc.titlePrimate Amygdala Neurons Simulate Decision Processes of Social Partners.en
dc.typeArticle
prism.endingPage998.e15
prism.issueIdentifier4en
prism.publicationDate2019en
prism.publicationNameCellen
prism.startingPage986
prism.volume177en
dc.identifier.doi10.17863/CAM.37402
dcterms.dateAccepted2019-02-25en
rioxxterms.versionofrecord10.1016/j.cell.2019.02.042en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2019-05en
dc.contributor.orcidGrabenhorst, Fabian [0000-0002-6455-0648]
dc.contributor.orcidBáez-Mendoza, Raymundo [0000-0002-5989-7647]
dc.contributor.orcidDeco, Gustavo [0000-0002-8995-7583]
dc.contributor.orcidSchultz, Wolfram [0000-0002-8530-4518]
dc.identifier.eissn1097-4172
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (095495/Z/11/Z)
pubs.funder-project-idEuropean Research Council (293549)
pubs.funder-project-idWellcome Trust (206207/Z/17/Z)
pubs.funder-project-idWellcome Trust (204811/Z/16/Z)
cam.orpheus.successThu Jan 30 10:49:28 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-05-02


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