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dc.contributor.authorMoylett, Sineaden
dc.contributor.authorPrice, Annabelen
dc.contributor.authorCardinal, Rudolfen
dc.contributor.authorAarsland, Dagen
dc.contributor.authorMueller, Christophen
dc.contributor.authorStewart, Roben
dc.contributor.authorO'Brien, Johnen
dc.date.accessioned2019-03-06T00:30:28Z
dc.date.available2019-03-06T00:30:28Z
dc.date.issued2019-01en
dc.identifier.issn1387-2877
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/290251
dc.description.abstractBackground: Dementia with Lewy bodies (DLB) is the second most common degenerative dementia in older people. However, rates of misdiagnosis are high, and little is known of its natural history and outcomes. Very few previous studies have been able to access routine clinical information for large, unbiased DLB cohorts in order to establish initial presentation, neuropsychological profile and mortality. Objective: To examine in detail, symptom patterns at presentation and their association with outcomes, including mortality, in a large naturalistic DLB cohort from a secondary care sample. Methods: A retrospective cohort design was used to identify a DLB cohort (n = 251) from Cambridge and Peterborough NHS Foundation Trust (CPFT). Information relating to first consultation, diagnosis, and DLB diagnostic features were extracted. Results: A wide range of presenting complaints and differential initial diagnoses were identified for the cohort. Along with memory loss (27.1%) and hallucinations (25.4%), low mood (25.1%) was noted as a key presenting complaint among the DLB cohort. Rates of REM sleep disorder were considerably lower (8.4%) than would be expected. Deficits in non-amnestic cognitive domains were associated with reduced mortality compared with amnestic-only presentations. Conclusion: Individuals later diagnosed with DLB present initially to secondary care with a wide range of symptoms and complaints, some of which are not immediately suggestive of a DLB diagnosis. More examinations of large cohorts such as this are needed to further elucidate the complex presentation and clinical course of DLB, and to confirm whether amnestic-only presentation confers a worse outcome. Key words: Dementia with Lewy bodies; Clinical presentation; Diagnostic features; Mortality; Retrospective cohort
dc.description.sponsorshipAlzheimer's Society; CPFT; NIHR Cambridge Biomedical Research Centre
dc.format.mediumPrinten
dc.languageengen
dc.publisherIOS Press
dc.subjectHumansen
dc.subjectLewy Body Diseaseen
dc.subjectSleep Deprivationen
dc.subjectDisease Progressionen
dc.subjectDiagnosis, Differentialen
dc.subjectSurvival Analysisen
dc.subjectRetrospective Studiesen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectMental Status and Dementia Testsen
dc.titleClinical Presentation, Diagnostic Features, and Mortality in Dementia with Lewy Bodies.en
dc.typeArticle
prism.endingPage1005
prism.issueIdentifier3en
prism.publicationDate2019en
prism.publicationNameJournal of Alzheimer's disease : JADen
prism.startingPage995
prism.volume67en
dc.identifier.doi10.17863/CAM.37481
dcterms.dateAccepted2018-08-27en
rioxxterms.versionofrecord10.3233/jad-180877en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-01en
dc.contributor.orcidMoylett, Sinead [0000-0002-2874-8307]
dc.contributor.orcidPrice, Annabel [0000-0002-5505-5231]
dc.contributor.orcidCardinal, Rudolf [0000-0002-8751-5167]
dc.contributor.orcidO'Brien, John [0000-0002-0837-5080]
dc.identifier.eissn1875-8908
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_PC_17213)


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