Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation and late-life activities
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Authors
Chan, D
Shafto, Meredith
Spink, Molly
Valenzuela, Michael
Publication Date
2018-10-01Journal Title
Neurobiology of Aging
ISSN
0197-4580
Publisher
Elsevier
Volume
70
Pages
180-183
Language
English
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Chan, D., Shafto, M., Kievit, R., Matthews, F., Spink, M., Valenzuela, M., & Henson, R. (2018). Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation and late-life activities. Neurobiology of Aging, 70 180-183. https://doi.org/10.1016/j.neurobiolaging.2018.06.012
Abstract
This study tested the hypothesis that mid-life intellectual, physical and social activities contribute to cognitive reserve (CR). Two hundred and five individuals (196 with MRI) aged 66-88 from the Cambridge Centre for Ageing and Neuroscience (www.cam-can.com) were studied, with cognitive ability and structural brain health measured as fluid IQ and total grey matter volume, respectively. Mid-life activities were measured using the Lifetime of Experiences Questionnaire.
Multivariable linear regression found that mid-life activities (MA) made a unique contribution to late-life cognitive ability independent of education, occupation and late-life activities. Crucially, MA moderated the relationship between late-life cognitive ability and brain health, with the cognitive ability of people with higher MA less dependent on their brain structure, consistent with the concept of CR.
In conclusion, mid-life activities contribute uniquely to CR. The modifiability of these activities has implications for public health initiatives aimed at dementia prevention.
Sponsorship
Cambridge NIHR Biomedical Research Centre
Funder references
MRC (unknown)
Biotechnology and Biological Sciences Research Council (BB/H008217/1)
European Commission (732592)
Medical Research Council (MC_UU_00005/8)
Medical Research Council (MC_UP_1401/1)
Medical Research Council (MC_UU_00005/9)
Medical Research Council (MC_UU_00005/12)
Identifiers
External DOI: https://doi.org/10.1016/j.neurobiolaging.2018.06.012
This record's URL: https://www.repository.cam.ac.uk/handle/1810/290421
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc-nd/4.0/
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