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D-optimal designs for multiarm trials with dropouts.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Biedermann, Stefanie 
Mitra, Robin 

Abstract

Multiarm trials with follow-up on participants are commonly implemented to assess treatment effects on a population over the course of the studies. Dropout is an unavoidable issue especially when the duration of the multiarm study is long. Its impact is often ignored at the design stage, which may lead to less accurate statistical conclusions. We develop an optimal design framework for trials with repeated measurements, which takes potential dropouts into account, and we provide designs for linear mixed models where the presence of dropouts is noninformative and dependent on design variables. Our framework is illustrated through redesigning a clinical trial on Alzheimer's disease, whereby the benefits of our designs compared with standard designs are demonstrated through simulations.

Description

Keywords

available case analysis, design of experiments, linear mixed models, noninformative dropouts, Clinical Trials as Topic, Computer Simulation, Humans, Linear Models, Patient Dropouts, Research Design

Journal Title

Stat Med

Conference Name

Journal ISSN

0277-6715
1097-0258

Volume Title

38

Publisher

Wiley
Sponsorship
Medical Research Council (MR/N028171/1)
Grant codes MR∕N028171∕ and MC_UP_1302∕4