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dc.contributor.authorBarr, Jennifer
dc.contributor.authorTodd, Shawn
dc.contributor.authorCrameri, Gary
dc.contributor.authorFoord, Adam
dc.contributor.authorMarsh, Glenn
dc.contributor.authorFrazer, Leah
dc.contributor.authorPayne, Jean
dc.contributor.authorHarper, Jenni
dc.contributor.authorBaker, Kate S
dc.contributor.authorCunningham, Andrew A
dc.contributor.authorWood, James
dc.contributor.authorMiddleton, Deborah
dc.contributor.authorWang, Lin-Fa
dc.date.accessioned2019-03-12T00:30:45Z
dc.date.available2019-03-12T00:30:45Z
dc.date.issued2018-08-24
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/290451
dc.description.abstractBats are implicated as the natural reservoirs for several highly pathogenic viruses that can infect other animal species, including man. Here, we investigate the potential for two recently discovered bat rubulaviruses, Achimota virus 1 (AchPV1) and Achimota virus 2 (AchPV2), isolated from urine collected under urban bat (Eidolon helvum) roosts in Ghana, West Africa, to infect small laboratory animals. AchPV1 and AchPV2 are classified in the family Paramyxoviridae and cluster with other bat derived zoonotic rubulaviruses (i.e. Sosuga, Menangle and Tioman viruses). To assess the susceptibility of AchPV1 and AchPV2 in animals, infection studies were conducted in ferrets, guinea pigs and mice. Seroconversion, immunohistological evidence of infection, and viral shedding were identified in ferrets and guinea pigs, but not in mice. Infection was associated with respiratory disease in ferrets. Viral genome was detected in a range of tissues from ferrets and guinea pigs, however virus isolation was only achieved from ferret tissues. The results from this study indicate Achimota viruses (AchPVs) are able to cross the species barrier. Consequently, vigilance for infection with and disease caused by these viruses in people and domesticated animals is warranted in sub-Saharan Africa and the Arabian Peninsula where the reservoir hosts are present.
dc.description.sponsorshipRoyal Society Wolfson research merit award. NRF-CRP grant (NRF2012NRF-CRP001-056).
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBronchi
dc.subjectEpithelial Cells
dc.subjectAnimals
dc.subjectMice, Inbred BALB C
dc.subjectFerrets
dc.subjectChiroptera
dc.subjectGuinea Pigs
dc.subjectParamyxoviridae
dc.subjectViremia
dc.subjectParamyxoviridae Infections
dc.subjectRNA, Viral
dc.subjectAntibodies, Viral
dc.subjectAntigens, Viral
dc.subjectNeutralization Tests
dc.subjectVirus Shedding
dc.subjectTime Factors
dc.subjectFemale
dc.subjectMale
dc.titleAnimal infection studies of two recently discovered African bat paramyxoviruses, Achimota 1 and Achimota 2.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameSci Rep
prism.startingPage12744
prism.volume8
dc.identifier.doi10.17863/CAM.37678
dcterms.dateAccepted2018-08-13
rioxxterms.versionofrecord10.1038/s41598-018-31193-z
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-08-24
dc.contributor.orcidBarr, Jennifer [0000-0001-5266-9142]
dc.contributor.orcidMarsh, Glenn [0000-0002-3469-1837]
dc.contributor.orcidCunningham, Andrew A [0000-0002-3543-6504]
dc.contributor.orcidWood, James [0000-0002-0258-3188]
dc.contributor.orcidWang, Lin-Fa [0000-0003-2752-0535]
dc.identifier.eissn2045-2322
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (106690/Z/14/Z)
cam.issuedOnline2018-08-24


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International