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G-Quadruplexes: Prediction, Characterization, and Biological Application.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Kwok, Chun Kit 
Merrick, Catherine J 

Abstract

Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention for decades. Recent methodological advances have advanced the identification and characterization of G-quadruplexes in vivo as well as in vitro, and at a much higher resolution and throughput, which has greatly expanded our current understanding of G-quadruplex structure and function. Accumulating knowledge about the structural properties of G-quadruplexes has helped to design and develop a repertoire of molecular and chemical tools for biological applications. This review highlights how these exciting methods and findings have opened new doors to investigate the potential functions and applications of G-quadruplexes in basic and applied biosciences.

Description

Keywords

G-quadruplex, aptamer, biosensing, cell imaging, next-generation sequencing, nucleic acid structure, Animals, Biomedical Research, Biosensing Techniques, G-Quadruplexes, Humans

Journal Title

Trends Biotechnol

Conference Name

Journal ISSN

0167-7799
1879-3096

Volume Title

35

Publisher

Elsevier BV
Sponsorship
Medical Research Council (MR/P010873/2)