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dc.contributor.authorAbbosh, Cen
dc.contributor.authorBirkbak, NJen
dc.contributor.authorWilson, GAen
dc.contributor.authorJamal-Hanjani, Men
dc.contributor.authorConstantin, Ten
dc.contributor.authorSalari, Ren
dc.contributor.authorLe Quesne, Jen
dc.contributor.authorMoore, DAen
dc.contributor.authorVeeriah, Sen
dc.contributor.authorRosenthal, Ren
dc.contributor.authorMarafioti, Ten
dc.contributor.authorKirkizlar, Een
dc.contributor.authorWatkins, TBKen
dc.contributor.authorMcGranahan, Nen
dc.contributor.authorWard, Sen
dc.contributor.authorMartinson, Len
dc.contributor.authorRiley, Jen
dc.contributor.authorFraioli, Fen
dc.contributor.authorAl Bakir, Men
dc.contributor.authorGrönroos, Een
dc.contributor.authorZambrana, Fen
dc.contributor.authorEndozo, Ren
dc.contributor.authorBi, WLen
dc.contributor.authorFennessy, FMen
dc.contributor.authorSponer, Nen
dc.contributor.authorJohnson, Den
dc.contributor.authorLaycock, Jen
dc.contributor.authorShafi, Sen
dc.contributor.authorCzyzewska-Khan, Jen
dc.contributor.authorRowan, Aen
dc.contributor.authorChambers, Ten
dc.contributor.authorMatthews, Nen
dc.contributor.authorTurajlic, Sen
dc.contributor.authorHiley, Cen
dc.contributor.authorLee, SMen
dc.contributor.authorForster, MDen
dc.contributor.authorAhmad, Ten
dc.contributor.authorFalzon, Men
dc.contributor.authorBorg, Een
dc.contributor.authorLawrence, Den
dc.contributor.authorHayward, Men
dc.contributor.authorKolvekar, Sen
dc.contributor.authorPanagiotopoulos, Nen
dc.contributor.authorJanes, SMen
dc.contributor.authorThakrar, Ren
dc.contributor.authorAhmed, Aen
dc.contributor.authorBlackhall, Fen
dc.contributor.authorSummers, Yen
dc.contributor.authorHafez, Den
dc.contributor.authorNaik, Aen
dc.contributor.authorGanguly, Aen
dc.contributor.authorKareht, Sen
dc.contributor.authorShah, Ren
dc.contributor.authorJoseph, Len
dc.contributor.authorMarie Quinn, Aen
dc.contributor.authorCrosbie, PAen
dc.contributor.authorNaidu, Ben
dc.contributor.authorMiddleton, Gen
dc.contributor.authorLangman, Gen
dc.contributor.authorTrotter, Sen
dc.contributor.authorNicolson, Men
dc.contributor.authorRemmen, Hen
dc.contributor.authorKerr, Ken
dc.contributor.authorChetty, Men
dc.contributor.authorGomersall, Len
dc.contributor.authorFennell, DAen
dc.contributor.authorNakas, Aen
dc.contributor.authorRathinam, Sen
dc.contributor.authorAnand, Gen
dc.contributor.authorKhan, Sen
dc.contributor.authorRussell, Pen
dc.contributor.authorEzhil, Ven
dc.contributor.authorIsmail, Ben
dc.contributor.authorIrvin-Sellers, Men
dc.contributor.authorPrakash, Ven
dc.contributor.authorLester, JFen
dc.contributor.authorKornaszewska, Men
dc.contributor.authorAttanoos, Ren
dc.contributor.authorAdams, Hen
dc.contributor.authorDavies, Hen
dc.contributor.authorOukrif, Den
dc.contributor.authorAkarca, AUen
dc.contributor.authorHartley, JAen
dc.contributor.authorLowe, HLen
dc.contributor.authorLock, Sen
dc.contributor.authorIles, Nen
dc.contributor.authorBell, Hen
dc.contributor.authorNgai, Yen
dc.contributor.authorElgar, Gen
dc.contributor.authorSzallasi, Zen
dc.contributor.authorSchwarz, RFen
dc.contributor.authorHerrero, Jen
dc.contributor.authorStewart, Aen
dc.contributor.authorQuezada, SAen
dc.contributor.authorPeggs, KSen
dc.contributor.authorVan Loo, Pen
dc.contributor.authorDive, Cen
dc.contributor.authorLin, CJen
dc.contributor.authorRabinowitz, Men
dc.contributor.authorAerts, HJWLen
dc.contributor.authorHackshaw, Aen
dc.contributor.authorShaw, JAen
dc.contributor.authorZimmermann, BGen
dc.contributor.authorTRACERx consortium,en
dc.contributor.authorPEACE consortium,en
dc.contributor.authorSwanton, Cen
dc.date.accessioned2019-03-19T10:49:49Z
dc.date.available2019-03-19T10:49:49Z
dc.date.issued2017-04-26en
dc.identifier.issn0028-0836
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/290640
dc.description.abstractThe early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies.
dc.languageengen
dc.publisherNature Publishing Group
dc.titlePhylogenetic ctDNA analysis depicts early-stage lung cancer evolution.en
dc.typeArticle
prism.endingPage451
prism.issueIdentifier7655en
prism.publicationDate2017en
prism.publicationNameNatureen
prism.startingPage446
prism.volume545en
dc.identifier.doi10.17863/CAM.24325
dcterms.dateAccepted2017-04-13en
rioxxterms.versionofrecord10.1038/nature22364en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-04-26en
dc.identifier.eissn1476-4687
rioxxterms.typeJournal Article/Reviewen


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