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dc.contributor.authorTijssen, Marloesen
dc.date.accessioned2019-03-21T13:53:32Z
dc.date.available2019-03-21T13:53:32Z
dc.date.issued2017-02-08en
dc.identifier.isbn978-3-319-39560-9en
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/290724
dc.description.abstractIt is now common knowledge that specific repertoires of transcription factors (TFs) determine a cell’s protein content and thereby its phenotype. The expression of a given TF is not necessarily cell specific, and many TFs play a pivotal role in several different cell types. For example, TAL1, FLI1, RUNX1, ERG and GATA2 are important regulators of stem cells, but also play a vital role in megakaryopoiesis. Although the megakaryocyte (MK) and its closest relative, the red blood cell, share key TFs like GATA1 and NFE2, the bifurcation between the two lineages has been associated with pairs of TFs that act as a toggle switch (such as FLI1 and KLF1). This chapter will summarise the current knowledge of key transcriptional regulators of MK differentiation and how some of these TFs, despite being expressed in several cell types, can impose MK cell identity. Since the discovery of TPO in 1994, our knowledge of MK biology and differentiation has increased exponentially, but we still lack a deep understanding of what triggers the transition from MK growth and maturation to proplatelet formation. We describe how some well-known TFs control the expression of proteins that play a pivotal role in the dramatic cytoplasmic and cytoskeletal events that accompany proplatelet formation. Finally, we show how TFs can be harnessed in a powerful way to produce MKs and, potentially, platelets in vitro for future clinical applications.en
dc.publisherSpringeren
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleTranscriptional Regulation of Platelet Formation: Harnessing the Complexity for Efficient Platelet Production In Vitroen
dc.typeBook chapter
prism.endingPage60
prism.number2en
prism.publicationDate2017en
prism.publicationNameMolecular and Cellular Biology of Platelet Formationen
prism.startingPage323
dc.identifier.doi10.17863/CAM.37923
rioxxterms.versionofrecord10.1007/978-3-319-39562-3_2en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-02-08en
rioxxterms.typeBook chapteren
cam.issuedOnline2017-02-08en
dc.identifier.urlhttps://link.springer.com/chapter/10.1007/978-3-319-39562-3_2#aboutcontenten


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International