Is breast implant-associated anaplastic large cell lymphoma a hazard of breast implant surgery?
The Royal Society
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Fitzal, F., Turner, S., & Kenner, L. (2019). Is breast implant-associated anaplastic large cell lymphoma a hazard of breast implant surgery?. Open biology, 9 (4), 190006. https://doi.org/10.1098/rsob.190006
Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) may occur after reconstructive or aesthetic breast surgery. Worldwide, approximately 1.7m breast implant surgeries are performed each year. To date, over 500 cases of BIA-ALCL have been reported around the World, with 16 women having died. This review highlights the most important facts surrounding BIA-ALCL. There is no consensus regarding the true incidence rate of BIA-ALCL as it varies between countries, is likely significantly under-reported and is difficult to estimate due to the true number of breast prostheses used largely being unknown. BIA-ALCL develops in the breast mostly as a seroma surrounding the implant, but contained within the fibrous capsule, or more rarely as a solid mass that can become invasive infiltrating the chest wall and muscle, in some instances spreading to adjacent lymph nodes, in these cases having a far worse prognosis. The causation of BIA-ALCL remains to be established, but it has been proposed that chronic infection and/or implant toxins may be involved. What is clear is that complete capsulectomy is required for treatment of BIA-ALCL, which for early stage disease leads to cure, whereas chemotherapy is needed for advanced-stage disease whereby improved results have been reported with the use of Brentuximab. A world-wide database for BIA-ALCL and implants should be supported by local governments.
Lymph Nodes, Humans, Breast Neoplasms, Breast Implantation, Mastectomy, Risk Factors, Breast Implants, Female, Lymphoma, Large-Cell, Anaplastic
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External DOI: https://doi.org/10.1098/rsob.190006
This record's URL: https://www.repository.cam.ac.uk/handle/1810/290778