Show simple item record

dc.contributor.authorDurcan, Roryen
dc.contributor.authorDonaghy, Paul Cen
dc.contributor.authorBarnett, Nicky Aen
dc.contributor.authorOlsen, Kirstyen
dc.contributor.authorYarnall, Alison Jen
dc.contributor.authorTaylor, John-Paulen
dc.contributor.authorMcKeith, Ianen
dc.contributor.authorO'Brien, Johnen
dc.contributor.authorThomas, Alan Jen
dc.date.accessioned2019-03-28T00:30:22Z
dc.date.available2019-03-28T00:30:22Z
dc.date.issued2019-07en
dc.identifier.issn0885-6230
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/290889
dc.description.abstractIntroduction: Lewy body disease is postulated, by the Braak model, to originate in the enteric nervous system, before spreading to the central nervous system. Therefore, a high prevalence of gastroparesis symptoms would be expected in prodromal dementia with Lewy bodies (DLB) and be highest in those with a dopaminergic deficit on imaging. The aim of this study was to explore whether gastroparesis was an early diagnostic marker of prodromal DLB and explore the relationship between symptoms and dopaminergic imaging findings on FP-CIT SPECT. Methods: We recruited 75 patients over 60 with mild cognitive impairment (MCI), 48 with MCI with suspected Lewy body disease (MCI-LB) and 27 with MCI with suspected Alzheimer’s disease (MCI-AD). All patients completed the Gastroparesis Cardinal Symptom Index (GSCI) questionnaire and also underwent FP-CIT [123I-N-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)] dopaminergic imaging. Results: At least one symptom suggestive of gastroparesis was reported in 48% (n=23) MCI-LB vs 37% MCI-AD (n=10) (P=0.36). Rates of definite symptoms of gastroparesis, as defined by a GCSI Total score ≥ 1.90, were rare and rates in MCI-LB were not different from MCI-AD (6% vs 0%, p=0.55). After adjusting for gender differences between groups, no difference in gastroparesis symptom prevalence (2.27 vs 0.81 P=0.05) or severity score (0.62 vs 0.28, p= 0.28) was noted between normally and abnormally visually rated FP-CIT SPECT scans. Conclusion: The GCSI is not a useful tool for differentiating MCI-LB from MCI-AD. A low rate of definite gastroparesis was detected in prodromal DLB. No association was found between gastroparesis symptoms and FP-CIT SPECT findings.
dc.description.sponsorshipNIHR BRC, GE Healthcare
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherJohn Wiley & Sons Inc.
dc.rightsAll rights reserved
dc.subjectHumansen
dc.subjectGastroparesisen
dc.subjectLewy Body Diseaseen
dc.subjectAlzheimer Diseaseen
dc.subjectTropanesen
dc.subjectTomography, Emission-Computed, Single-Photonen
dc.subjectPrevalenceen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectProdromal Symptomsen
dc.titlePrevalence and severity of symptoms suggestive of gastroparesis in prodromal dementia with Lewy bodies.en
dc.typeArticle
prism.endingPage998
prism.issueIdentifier7en
prism.publicationDate2019en
prism.publicationNameInternational journal of geriatric psychiatryen
prism.startingPage990
prism.volume34en
dc.identifier.doi10.17863/CAM.38073
dcterms.dateAccepted2019-03-17en
rioxxterms.versionofrecord10.1002/gps.5100en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-07en
dc.contributor.orcidDurcan, Rory [0000-0002-8897-8737]
dc.contributor.orcidDonaghy, Paul C [0000-0001-7195-4846]
dc.contributor.orcidYarnall, Alison J [0000-0002-3126-9163]
dc.contributor.orcidO'Brien, John [0000-0002-0837-5080]
dc.identifier.eissn1099-1166
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successThu Jan 30 10:48:15 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-07-31


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record