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dc.contributor.authorDareng, Eileen Oen
dc.contributor.authorAdebamowo, Sally Nen
dc.contributor.authorFamooto, Ayotundeen
dc.contributor.authorOlawande, Oluwatoyosien
dc.contributor.authorOdutola, Michael Ken
dc.contributor.authorOlaniyan, Yinkaen
dc.contributor.authorOffiong, Richard Aen
dc.contributor.authorPharoah, Paulen
dc.contributor.authorAdebamowo, Clement Aen
dc.date.accessioned2019-03-29T12:05:21Z
dc.date.available2019-03-29T12:05:21Z
dc.identifier.issn1471-2334
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/290967
dc.description.abstractBACKGROUND: Genital warts are important causes of morbidity and their prevalence and incidence can be used to evaluate the impact of HPV vaccination in a population. METHODS: We enrolled 1020 women in a prospective cohort study in Nigeria and followed them for a mean (SD) of 9 (4) months. Nurses conducted pelvic examinations and collected ectocervical samples for HPV testing. We used exact logistic regression models to identify risk factors for genital warts. RESULTS: The mean age of study participants was 38 years, 56% (535/962) were HIV-negative and 44% (427/962) were HIV-positive. Prevalence of genital warts at enrolment was 1% (4/535) among HIV-negative women, and 5% (23/427) among HIV-positive women. Of 614 women (307 HIV negative and 307 HIV positive women) for whom we could compute genital wart incidence, it was 515 (95% CI:13-2872) per 100,000 person-years in HIV-negative and 1370 (95% CI:283-4033) per 100,000 person-years in HIV-positive women. HIV was associated with higher risk of prevalent genital warts (OR:7.14, 95% CI:2.41-28.7, p < 0.001) while higher number of sex partners in the past year was associated with increased risk of incident genital warts (OR:2.86, 95% CI:1.04-6.47. p = 0.04). HPV11 was the only HPV associated with prevalent genital warts in this population (OR:8.21, 95% CI:2.47-27.3, p = 0.001). CONCLUSION: Genital warts are common in Nigeria and our results provide important parameters for monitoring the impact of future HPV vaccination programs in the country. HIV infection and number of sexual partners in past year were important risk factors for prevalent and incident genital warts respectively.
dc.description.sponsorshipThis study was funded by NIH grants – Capacity Development for Research in AIDS Associated Malignancies (NCI/NIH 1D43CA153792), African Collaborative Center for Microbiome and Genomics Research grants (NHGRI/NIH U54HG006947) and Greenebaum Comprehensive Cancer Center grant (NCI/NIH 5P30CA134274).
dc.languageengen
dc.publisherBioMed Central
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectEpidemiologyen
dc.subjectGenital tract infectionen
dc.subjectGenital wartsen
dc.subjectHIVen
dc.subjectHPVen
dc.subjectAdulten
dc.subjectCervix Uterien
dc.subjectCohort Studiesen
dc.subjectCondylomata Acuminataen
dc.subjectFemaleen
dc.subjectHIV Infectionsen
dc.subjectHIV Seronegativityen
dc.subjectHuman papillomavirus 11en
dc.subjectHumansen
dc.subjectIncidenceen
dc.subjectNigeriaen
dc.subjectPapillomavirus Infectionsen
dc.subjectPrevalenceen
dc.subjectProspective Studiesen
dc.subjectRisk Factorsen
dc.subjectSexual Partnersen
dc.titlePrevalence and incidence of genital warts and cervical Human Papillomavirus infections in Nigerian women.en
dc.typeArticle
prism.number27en
prism.publicationNameBMC Infectious Diseasesen
prism.volume19en
dc.identifier.doi10.17863/CAM.38146
dcterms.dateAccepted2018-12-03en
rioxxterms.versionofrecord10.1186/s12879-018-3582-yen
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2018-12-03en
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.identifier.eissn1471-2334
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (10119)
cam.issuedOnline2019-01-07en
dc.identifier.urlhttps://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-018-3582-yen


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International