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dc.contributor.authorMahmod, Masliza
dc.contributor.authorPal, Nikhil
dc.contributor.authorRayner, Jennifer
dc.contributor.authorHolloway, Cameron
dc.contributor.authorRaman, Betty
dc.contributor.authorDass, Sairia
dc.contributor.authorLevelt, Eylem
dc.contributor.authorAriga, Rina
dc.contributor.authorFerreira, Vanessa
dc.contributor.authorBanerjee, Rajarshi
dc.contributor.authorSchneider, Juergen
dc.contributor.authorRodgers, CT
dc.contributor.authorFrancis, Jane
dc.contributor.authorKaramitsos, Theodoros
dc.contributor.authorFrenneaux, Michael
dc.contributor.authorAshrafian, Houman
dc.contributor.authorNeubauer, Stefan
dc.contributor.authorRider, Oliver
dc.description.abstractBackground: Heart failure (HF) is characterized by altered myocardial substrate metabolism which can lead to myocardial triglyceride accumulation (steatosis) and lipotoxicity. However its role in mild HF with preserved ejection fraction (HFpEF) is uncertain. We measured myocardial triglyceride content (MTG) in HFpEF and assessed its relationships with diastolic function and exercise capacity. Methods: 27 HFpEF (clinical features of HF, left ventricular EF >50%, evidence of mild diastolic dysfunction and evidence of exercise limitation as assessed by cardiopulmonary exercise test) and 14 controls underwent 1H-magnetic resonance spectroscopy (1H-MRS) to measure MTG (lipid/water, %), 31P-MRS to measure myocardial energetics (phosphocreatine-to-adenosine triphosphate - PCr/ATP) and feature-tracking magnetic resonance imaging for diastolic strain rate. Results: When compared to controls, HFpEF had 2.3 fold higher in MTG (1.45±0.25% vs. 0.64±0.16%, p=0.009) and reduced PCr/ATP (1.60±0.09 vs. 2.00±0.10, p=0.005). HFpEF had significantly reduced diastolic strain rate and maximal oxygen consumption (VO2 max), which both correlated significantly with elevated MTG and reduced PCr/ATP. On multivariate analyses, MTG was independently associated with diastolic strain rate while diastolic strain rate was independently associated with VO2 max. Conclusions: Myocardial steatosis is pronounced in mild HFpEF, and is independently associated with impaired diastolic strain rate which is itself related to exercise capacity. Steatosis may adversely affect exercise capacity by indirect effect occurring via impairment in diastolic function. As such, myocardial triglyceride may become a potential therapeutic target to treat the increasing number of patients with HFpEF.
dc.description.sponsorshipThis work was supported by Chest Heart and Stroke Association, Scotland. MM acknowledges support from the National University of Malaysia and Ministry of Higher Education Malaysia. SN and OR acknowledge support from the Oxford NIHR Biomedical Research Centre and the Oxford British Heart Foundation Centre of Research Excellence. JES is a Senior BHF Basic Science Research Fellow (FS/11/50/29038). CTR is funded by a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society [098436/Z/12/Z/B]. OR is a BHF Clinical Intermediate Research Fellow FS/16/70/32157.
dc.publisherBMC - Springer Nature
dc.rightsAttribution 4.0 International
dc.titleThe interplay between metabolic alterations, diastolic strain rate and exercise capacity in mild heart failure with preserved ejection fraction
prism.publicationNameJournal Of Cardiovascular Magnetic Resonance
dc.contributor.orcidRodgers, Christopher [0000-0003-1275-1197]
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (Unknown)
pubs.funder-project-idWellcome Trust (098436/Z/12/Z)
pubs.funder-project-idWellcome Trust (098436/Z/12/B)
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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International