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dc.contributor.authorGawden-Bone, Christianen
dc.contributor.authorGriffiths, Gillianen
dc.date.accessioned2019-04-03T23:30:59Z
dc.date.available2019-04-03T23:30:59Z
dc.identifier.issn1664-3224
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291103
dc.description.abstractPhosphoinositides, together with the phospholipids phosphatidylserine and phosphatidic acid, are important components of the plasma membrane acting as second messengers that, with diacylglycerol, regulate a diverse range of signalling events converting extracellular changes into cellular responses. Local changes in their distribution and membrane charge on the inner leaflet of the plasma membrane play important roles in immune cell function. Here we discuss their distribution and regulators highlighting the importance of membrane changes across the immune synapse on the cytoskeleton and the impact on the function of cytotoxic T lymphocytes.
dc.description.sponsorshipResearch was funded by Wellcome Trust grants [103930] and [100140], to GMG.
dc.publisherFrontiers Media
dc.rightsAttribution 4.0 International (CC BY)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titlePhospholipids: pulling back the actin curtain for granule delivery to the immune synapseen
dc.typeArticle
prism.publicationNameFrontiers in Immunologyen
dc.identifier.doi10.17863/CAM.38284
dcterms.dateAccepted2019-03-14en
rioxxterms.versionofrecord10.3389/fimmu.2019.00700en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-03-14en
dc.contributor.orcidGawden-Bone, Christian [0000-0003-0413-3727]
dc.contributor.orcidGriffiths, Gillian [0000-0003-0434-5842]
dc.identifier.eissn1664-3224
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (075880/Z/04/A)
pubs.funder-project-idWELLCOME TRUST (103930/Z/14/Z)
pubs.funder-project-idWellcome Trust (100140/Z/12/Z)
cam.issuedOnline2019-04-11en
cam.orpheus.successTue Jun 16 10:41:28 BST 2020 - The item has an open VoR version.*
cam.orpheus.counter12*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International (CC BY)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY)