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dc.contributor.authorGrist, James Timothy
dc.date.accessioned2019-04-04T14:25:45Z
dc.date.available2019-04-04T14:25:45Z
dc.date.issued2019-05-08
dc.date.submitted2018-07-26
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291148
dc.description.abstractMetabolism is a key process to the function and survival of all living organisms. The role of metabolism is key in many pathologies, and presents a prime opportunity to both understand and treat disease in new ways. In particular, lactate is a molecule which has been known and studied for many years by a broad spectrum of scientists from many research fields, with it appearing to have a number of roles in the routine operation and function of living organisms, as well as signaling pathological disturbance of normal physiology in many circumstances. This thesis aims to further the understanding of how measuring and quantifying both lactate and sodium with both NMR and spectral photometric techniques can be a powerful tool for the researcher in cell, pre-clinical, and clinical research. The research for my PhD has focused on basic biology, pre-clinical large animal imaging, clinical sodium imaging in Multiple Sclerosis, and a physiological first in man study of the healthy brain with hyperpolarised [1-13C] pyruvate.
dc.description.sponsorshipMedical Research Council, Aarhus Unviersity
dc.language.isoen
dc.rightsAll rights reserved
dc.rightsAll Rights Reserveden
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved/en
dc.subjectRadiolgy
dc.subjectmetabolism
dc.subjectMRI
dc.subjectMultiple Sclerosis
dc.subjectClinical
dc.titleImaging and Measuring Cerebral Metabolism in the Healthy Brain and Changes Following Inflammation
dc.typeThesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (PhD)
dc.publisher.institutionUniversity of Cambridge
dc.publisher.departmentRadiology
dc.date.updated2019-03-30T07:29:43Z
dc.identifier.doi10.17863/CAM.38330
dc.contributor.orcidGrist, James Timothy [0000-0001-7223-4031]
dc.publisher.collegeGonville and Caius
dc.type.qualificationtitleRadiology
cam.supervisorGalalgher, Ferdia Aiden
cam.supervisorColes, Alasdari
cam.thesis.fundingtrue


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