Impact of Locally Administered Carboxydextran-Coated Super-Paramagnetic Iron Nanoparticles on Cellular Immune Function.
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Publication Date
2019-05Journal Title
Small (Weinheim an der Bergstrasse, Germany)
ISSN
1613-6810
Publisher
Wiley - V C H Verlag GmbbH & Co.
Volume
15
Issue
20
Pages
e1900224
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Pedro, L., Harmer, Q., Mayes, E., & Shields, J. (2019). Impact of Locally Administered Carboxydextran-Coated Super-Paramagnetic Iron Nanoparticles on Cellular Immune Function.. Small (Weinheim an der Bergstrasse, Germany), 15 (20), e1900224. https://doi.org/10.1002/smll.201900224
Abstract
Interstitially-administered iron oxide particles are currently used for inter-operative localization of sentinel lymph nodes (SLNs) in cancer staging. Several studies have described concerns regarding the cellular accumulation of iron oxide nanoparticles relating them to phenotype and function deregulation of macrophages, impairing their ability to mount an appropriate immune response once an insult is present. This study aimed to address what phenotypic and functional changes occur during lymphatic transit and accumulation of these particles. Data shows that 60 nm carboxydextran-coated iron nanoparticles use a non-cellular mechanism to reach the draining LN and that their accumulation in macrophages induces transient phenotypic and functional changes. Nevertheless, macrophages recover their baseline levels of response within 7 days, and are still able to mount an appropriate response to bacterially-induced inflammation.
Keywords
Cell Line, Macrophages, Animals, Mice, Inbred C57BL, Mice, Inflammation, Dextrans, Phenotype, Magnetite Nanoparticles, RAW 264.7 Cells, Sentinel Lymph Node
Sponsorship
MRC Core funding
Funder references
Medical Research Council (MC_UU_12022/5)
MRC (MC_UU_12022/1_do not transfer?)
Identifiers
External DOI: https://doi.org/10.1002/smll.201900224
This record's URL: https://www.repository.cam.ac.uk/handle/1810/291219
Rights
All rights reserved