Show simple item record

dc.contributor.authorPedro, Luisaen
dc.contributor.authorHarmer, Quentinen
dc.contributor.authorMayes, Ericen
dc.contributor.authorShields, Jacquelineen
dc.date.accessioned2019-04-05T23:31:13Z
dc.date.available2019-04-05T23:31:13Z
dc.date.issued2019-05en
dc.identifier.issn1613-6810
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291219
dc.description.abstractInterstitially-administered iron oxide particles are currently used for inter-operative localization of sentinel lymph nodes (SLNs) in cancer staging. Several studies have described concerns regarding the cellular accumulation of iron oxide nanoparticles relating them to phenotype and function deregulation of macrophages, impairing their ability to mount an appropriate immune response once an insult is present. This study aimed to address what phenotypic and functional changes occur during lymphatic transit and accumulation of these particles. Data shows that 60 nm carboxydextran-coated iron nanoparticles use a non-cellular mechanism to reach the draining LN and that their accumulation in macrophages induces transient phenotypic and functional changes. Nevertheless, macrophages recover their baseline levels of response within 7 days, and are still able to mount an appropriate response to bacterially-induced inflammation.
dc.description.sponsorshipMRC Core funding
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherWiley - V C H Verlag GmbbH & Co.
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectCell Lineen
dc.subjectMacrophagesen
dc.subjectAnimalsen
dc.subjectMice, Inbred C57BLen
dc.subjectMiceen
dc.subjectInflammationen
dc.subjectDextransen
dc.subjectPhenotypeen
dc.subjectMagnetite Nanoparticlesen
dc.subjectRAW 264.7 Cellsen
dc.subjectSentinel Lymph Nodeen
dc.titleImpact of Locally Administered Carboxydextran-Coated Super-Paramagnetic Iron Nanoparticles on Cellular Immune Function.en
dc.typeArticle
prism.issueIdentifier20en
prism.publicationDate2019en
prism.publicationNameSmall (Weinheim an der Bergstrasse, Germany)en
prism.startingPagee1900224
prism.volume15en
dc.identifier.doi10.17863/CAM.38398
dcterms.dateAccepted2019-03-12en
rioxxterms.versionofrecord10.1002/smll.201900224en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-05en
dc.contributor.orcidPedro, Luisa [0000-0003-0744-8484]
dc.contributor.orcidHarmer, Quentin [0000-0002-0271-3958]
dc.contributor.orcidMayes, Eric [0000-0003-3295-029X]
dc.contributor.orcidShields, Jacqueline [0000-0003-2153-9710]
dc.identifier.eissn1613-6829
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMedical Research Council (MC_UU_12022/5)
pubs.funder-project-idMRC (MC_UU_12022/1_do not transfer?)
cam.orpheus.successThu Jan 30 10:47:39 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-05-31


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record