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dc.contributor.authorRuprecht, Jonathanen
dc.contributor.authorKunji, Edmunden
dc.date.accessioned2019-04-05T23:31:30Z
dc.date.available2019-04-05T23:31:30Z
dc.date.issued2019-08en
dc.identifier.issn0959-440X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291230
dc.description.abstractThe mitochondrial ADP/ATP carrier, also called adenine nucleotide translocase, accomplishes one of the most important transport activities in eukaryotic cells, importing ADP into the mitochondrial matrix for ATP synthesis, and exporting ATP to fuel cellular activities. In the transport cycle, the carrier changes between a cytoplasmic and matrix state, in which the central substrate binding site is alternately accessible to these compartments. A structure of a cytoplasmic state was known, but recently, a structure of a matrix-state in complex with bongkrekic acid was solved. Comparison of the two states explains the function of highly conserved sequence features and reveals that the transport mechanism is unique, involving the coordinated movement of six dynamic elements around a central translocation pathway.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHumansen
dc.subjectMitochondrial ADP, ATP Translocasesen
dc.subjectCrystallography, X-Rayen
dc.subjectBiological Transporten
dc.subjectHydrogen Bondingen
dc.titleStructural changes in the transport cycle of the mitochondrial ADP/ATP carrier.en
dc.typeArticle
prism.endingPage144
prism.publicationDate2019en
prism.publicationNameCurrent opinion in structural biologyen
prism.startingPage135
prism.volume57en
dc.identifier.doi10.17863/CAM.38409
dcterms.dateAccepted2019-03-20en
rioxxterms.versionofrecord10.1016/j.sbi.2019.03.029en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-08en
dc.contributor.orcidRuprecht, Jonathan [0000-0002-1838-7245]
dc.contributor.orcidKunji, Edmund [0000-0002-0610-4500]
dc.identifier.eissn1879-033X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_U105663139)
pubs.funder-project-idMRC (MC_UU_00015/1)
cam.orpheus.successThu Jan 30 10:47:37 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-08-31


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International