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dc.contributor.authorBhattacharya, Indrani Sen
dc.contributor.authorHaviland, Joanne Sen
dc.contributor.authorPerotti, Carolaen
dc.contributor.authorEaton, Daviden
dc.contributor.authorGulliford, Sarahen
dc.contributor.authorHarris, Emmaen
dc.contributor.authorColes, Charlotteen
dc.contributor.authorKirwan, Cliona Cen
dc.contributor.authorBliss, Judith Men
dc.contributor.authorKirby, Anna Men
dc.contributor.authorIMPORT Trialists,en
dc.date.accessioned2019-04-05T23:32:18Z
dc.date.available2019-04-05T23:32:18Z
dc.date.issued2019-07en
dc.identifier.issn0167-8140
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291263
dc.description.abstractBackground: Seroma describes a collection of serous fluid within a cavity, occurring following surgery. Seroma is associated with normal tissue effects (NTE) following breast radiotherapy, as reported by clinicians and on photographs. This study investigates the association between seroma and the NTE breast appearance change collected using patient-reported outcome measures (PROMs) in IMPORT HIGH, as well as investigating the association between breast appearance change and patient/tumour/treatment factors. Methods: Case-control methodology was used for seroma analysis within IMPORT HIGH. Cases were patients reporting moderate/marked breast appearance change and controls reported none/mild changes at year-3. One control was selected at random for each case. Seromas were graded as not visible/subtle or visible/highly visible on CT radiotherapy planning scans. Logistic regression tested associations, adjusting for patient/tumour/treatment factors. Results: 1078/1149 patients consented to PROMs, of whom 836 (78%) reported whether they had 3-year breast appearance change; 231 cases and 231 controls were identified. 304/462 (66%) patients received chemotherapy. Seroma prevalence was 20% (41/202) in cases and 16% (32/205) in controls, and less frequent in patients receiving adjuvant chemotherapy [10% (24/246) compared with 29% (40/138) without]. Visible seroma was not significantly associated with breast appearance change [OR 1.38 (95%CI 0.83-2.29), p=0.219]. Larger tumour size, haematoma, current smoking and body image concerns at baseline were independent risk factors. Conclusions: Seroma was not associated with patient-reported breast appearance change, but haematoma and smoking were significant risk factors. Lack of association may be related to lower prevalence of seroma compared with previous reports, perhaps reflecting patients receiving adjuvant chemotherapy in whom seroma resolves prior to radiotherapy.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectIMPORT Trialistsen
dc.subjectBreasten
dc.subjectHumansen
dc.subjectBreast Neoplasmsen
dc.subjectSeromaen
dc.subjectCombined Modality Therapyen
dc.subjectLogistic Modelsen
dc.subjectRisk Factorsen
dc.subjectCase-Control Studiesen
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectPatient Reported Outcome Measuresen
dc.titleIs breast seroma after tumour resection associated with patient-reported breast appearance change following radiotherapy? Results from the IMPORT HIGH (CRUK/06/003) trial.en
dc.typeArticle
prism.endingPage196
prism.publicationDate2019en
prism.publicationNameRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncologyen
prism.startingPage190
prism.volume136en
dc.identifier.doi10.17863/CAM.38442
dcterms.dateAccepted2019-03-24en
rioxxterms.versionofrecord10.1016/j.radonc.2019.03.022en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-07en
dc.contributor.orcidBhattacharya, Indrani S [0000-0002-2983-1305]
dc.contributor.orcidHaviland, Joanne S [0000-0001-5728-3636]
dc.contributor.orcidEaton, David [0000-0003-3994-110X]
dc.contributor.orcidColes, Charlotte [0000-0003-4473-8552]
dc.contributor.orcidKirwan, Cliona C [0000-0002-1725-4790]
dc.contributor.orcidBliss, Judith M [0000-0001-7957-7424]
dc.identifier.eissn1879-0887
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successThu Jan 30 10:47:31 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-07-31


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International