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dc.contributor.authorSushentsev, Nen
dc.contributor.authorMartin, Henno Wolfgangen
dc.contributor.authorRimmer, Yen
dc.contributor.authorBarrett, Tristanen
dc.date.accessioned2019-04-05T23:32:38Z
dc.date.available2019-04-05T23:32:38Z
dc.identifier.issn1699-048X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291277
dc.description.abstractPURPOSE: To evaluate the added value of diffusion-weighted imaging (DWI) to T2-weighted imaging (T2WI) for improved identification of pelvic lymph nodes (LN) by radiation oncologists. METHODS/PATIENTS: This retrospective study included 20 patients with histopathologically proven node-negative prostate cancer. All patients underwent 3T-MRI of the prostate; matched axial T2WI and DWI sequences were assessed by an experienced uro-radiologist as the reference standard. Consultant and specialist registrar radiation oncologists were asked to identify all LN first on T2WI alone (read 1) and then on T2WI and DWI combined (read 2); LN were measured in size and divided into true positives (TP), false positives (FP) and false negatives (FN). Sensitivity, positive predictive value (PPV) and false negative rate (FNR) were then calculated and compared using Pearson's Chi square test. RESULTS: A total of 177 LN comprised the reference standard. 16 TP, 16 FP and 161 FN LN (sensitivity 9.0%, PPV 50.0%, FNR 91.0%) and 124, 15 and 53 LN (70.1%, 89.2%, 30%) were identified by reader 1 on reads 1 and 2, respectively; χ2 (2, N = 385) = 137.8, p < 0.0001. 27, 21 and 150 LN (15.3%, 56.3%, 84.8%) and 120, 13 and 57 LN (67.8%, 90.2%, 32.2%) were identified by reader 2 on the two reads; χ2 (2, N = 388) = 102.4, p < 0.0001. CONCLUSIONS: Adding DWI to T2WI significantly improved identification of pelvic LN by radiation oncologists and can therefore be regarded as a useful LN contouring technique for RT planning in pelvic malignancies.
dc.description.sponsorshipAuthor T. Barrett acknowledges support from Cancer Research UK, National Institute of Health Research Cambridge Biomedical Research Centre, Cancer Research UK and the Engineering and Physical Sciences Research Council Imaging Centre in Cambridge and Manchester and the Cambridge Experimental Cancer Medicine Centre.
dc.languageengen
dc.publisherSpringer-Verlag Italia
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectDiffusion-weighted imagingen
dc.subjectLymph nodesen
dc.subjectMRIen
dc.subjectPelvic malignanciesen
dc.subjectProstate canceren
dc.subjectRadiotherapy planningen
dc.titleAdded value of diffusion-weighted MRI for nodal radiotherapy planning in pelvic malignancies.en
dc.typeArticle
prism.publicationNameClinical and Translational Oncologyen
dc.identifier.doi10.17863/CAM.38456
dcterms.dateAccepted2019-02-15en
rioxxterms.versionofrecord10.1007/s12094-019-02068-0en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-02-15en
dc.contributor.orcidBarrett, Tristan [0000-0002-1180-1474]
dc.identifier.eissn1699-3055
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2019-03-13en
cam.orpheus.successThu Jan 30 10:47:29 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-03-13


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