Discussion of "Gene hunting with hidden Markov model knockoffs'
Oxford University Press
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Bottolo, L., & Richardson, S. (2019). Discussion of "Gene hunting with hidden Markov model knockoffs'. Biometrika, 106 (1), 19-22. https://doi.org/10.1093/biomet/asy063
We congratulate the authors on this interesting paper that tackles the difficult problem of extending the work of Candès et al. (2018) to structured predictors possessing a particular type of dependence. Motivated by the aim of making the knockoff construction applicable to genome-wide association studies, Sesia et al. (2019) propose using a hidden Markov model to generate knockoffs that capture patterns of DNA variation, following the work of Scheet & Stephens (2006).
EPSRC (via Lancaster University) (EP/R018561/1)
Alan Turing Institute (Unknown)
External DOI: https://doi.org/10.1093/biomet/asy063
This record's URL: https://www.repository.cam.ac.uk/handle/1810/291280
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/